Blar i Bergen Open Research Archive på tidsskrift "Cell Genomics"

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    • Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy 

      Kleeman, Sam O.; Thakir, Tuba Mansoor; Demestichas, Breanna; Mourikis, Nicholas; Loiero, Dominik; Ferrer, Miriam; Bankier, Sean; Riazat-Kesh, Yosef J.R.A.; Lee, Hassal; Chantzichristos, Dimitrios; Regan, Claire; Preall, Jonathan; Sinha, Sarthak; Rosin, Nicole; Yipp, Bryan; de Almeida, Luiz G.N.; Biernaskie, Jeff; Dufour, Antoine; Tober-Lau, Pinkus; Ruusalepp, Arno; Bjorkegren, Johan L.M.; Ralser, Markus; Kurth, Florian; Demichev, Vadim; Heywood, Todd; Gao, Qing; Johannsson, Gudmundur; Koelzer, Viktor H.; Walker, Brian R.; Meyer, Hannah V.; Janowitz, Tobias (Journal article; Peer reviewed, 2023)
      Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with ...

    • Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins 

      DeForest, Natalie; Kavitha, Babu; Hu, Siqi; Isaac, Roi; Krohn, Lynne; Wang, Minxian; Du, Xiaomi; De Arruda Saldanha, Camila; Gylys, Jenny; Merli, Edoardo; Abagyan, Ruben; Najmi, Laeya Abdoli; Mohan, Viswanathan; Flannick, Jason; Peloso, Gina M.; Gordts, Philip L.S.M.; Heinz, Sven; Deaton, Aimee M.; Khera, Amit V.; Olefsky, Jerrold; Radha, Venkatesan; Majithia, Amit R. (Journal article; Peer reviewed, 2023)
      Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ...