Blar i Bergen Open Research Archive på tidsskrift "ChemMedChem"
Viser treff 1-2 av 2
-
An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
(Journal article; Peer reviewed, 2021)FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ... -
Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors
(Journal article; Peer reviewed, 2021)The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of ...