Blar i Bergen Open Research Archive på tidsskrift "Frontiers in Genetics"
Viser treff 1-14 av 14
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Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2
(Peer reviewed; Journal article, 2018-02-22)Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which ... -
Autosomal sdY pseudogenes explain discordances between phenotypic sex and DNA marker for sex identification in Atlantic salmon
(Journal article; Peer reviewed, 2020)Despite the key role that sex-determination plays in evolutionary processes, it is still poorly understood in many species. In salmonids, which are among the best studied fishes, the master sex-determining gene sexually ... -
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms
(Peer reviewed; Journal article, 2019-09-26)Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten ... -
Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study
(Peer reviewed; Journal article, 2019-06-11)Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ... -
A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG
(Peer reviewed; Journal article, 2018-02-26)Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these ... -
High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering
(Journal article; Peer reviewed, 2019)Studying the impact of genetic variation on gene regulatory networks is essential to understand the biological mechanisms by which genetic variation causes variation in phenotypes. Bayesian networks provide an elegant ... -
Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis
(Journal article; Peer reviewed, 2022)Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ... -
Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
(Journal article; Peer reviewed, 2021)Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ... -
Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys
(Journal article; Peer reviewed, 2022)Bioenergetic organelles—mitochondria and plastids—retain their own genomes (mtDNA and ptDNA), and these organelle DNA (oDNA) molecules are vital for eukaryotic life. Like all genomes, oDNA must be able to evolve to suit ... -
Patterns of diversification amongst tropical regions compared: a case study in Sapotaceae
(Peer reviewed; Journal article, 2014-12-03)Species diversity is unequally distributed across the globe, with the greatest concentration occurring in the tropics. Even within the tropics, there are significant differences in the numbers of taxa found in each continental ... -
Quantitative PCR Measurement of miR-371a-3p and miR-372-p Is Influenced by Hemolysis
(Peer reviewed; Journal article, 2019-05-22)Cell-free microRNAs have been reported as biomarkers for several diseases. For testicular germ cell tumors (GCT), circulating microRNAs 371a-3p and 372-3p in serum and plasma have been proposed as biomarkers for diagnostic ... -
The risk of various types of cardiovascular diseases in mutation positive familial hypercholesterolemia; a review
(Journal article; Peer reviewed, 2022)Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein Cholesterol (LDL-C) from birth. Any diseases associated with increased LDL-C levels including ... -
Salmon louse labial gland enzymes: implications for host settlement and immune modulation
(Journal article; Peer reviewed, 2024)Salmon louse (Lepeophtheirus salmonis) is a skin- and blood-feeding ectoparasite, infesting salmonids. While feeding, labial gland proteins from the salmon louse may be deposited on the Atlantic salmon (Salmo salar) skin. ... -
Small Open Reading Frames, How to Find Them and Determine Their Function
(Journal article; Peer reviewed, 2022)Advances in genomics and molecular biology have revealed an abundance of small open reading frames (sORFs) across all types of transcripts. While these sORFs are often assumed to be non-functional, many have been implicated ...