Blar i Bergen Open Research Archive på tidsskrift "Genome Research"
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Accurate analysis of genuine CRISPR editing events with ampliCan
(Peer reviewed; Journal article, 2019)We present ampliCan, an analysis tool for genome editing that unites highly precise quantification and visualization of genuine genome editing events. ampliCan features nuclease-optimized alignments, filtering of experimental ... -
A chromosome-level assembly of the Atlantic herring genome-detection of a supergene and other signals of selection
(Peer reviewed; Journal article, 2019)The Atlantic herring is a model species for exploring the genetic basis for ecological adaptation, due to its huge population size and extremely low genetic differentiation at selectively neutral loci. However, such studies ... -
The circular RNome of primary breast cancer
(Peer reviewed; Journal article, 2019)Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs ... -
Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis
(Peer reviewed; Journal article, 2013)Spatiotemporal control of gene expression is central to animal development. Core promoters represent a previously unanticipated regulatory level by interacting with cis-regulatory elements and transcription initiation in ... -
Increased taxon sampling reveals thousands of hidden orthologs in flatworms
(Journal article; Peer reviewed, 2017)Gains and losses shape the gene complement of animal lineages and are a fundamental aspect of genomic evolution. Acquiring a comprehensive view of the evolution of gene repertoires is limited by the intrinsic limitations ...