Blar i Bergen Open Research Archive på tidsskrift "Neuropsychopharmacology"
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The association between lithium use and neurocognitive performance in patients with bipolar disorder
(Journal article; Peer reviewed, 2020)Lithium remains the gold standard for the treatment of bipolar disorder (BD); however, its use has declined over the years mainly due to the side effects and the subjective experience of cognitive numbness reported by ... -
Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator
(Journal article; Peer reviewed, 2021)Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their ... -
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
(Peer reviewed; Journal article, 2019)Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood ... -
Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study
(Peer reviewed; Journal article, 2019)Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium have been studied extensively and gene expression changes are generally believed to ... -
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
(Journal article; Peer reviewed, 2021)Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for ...