Blar i Bergen Open Research Archive på tidsskrift "Retrovirology"
Viser treff 1-7 av 7
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Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
(Peer reviewed; Journal article, 2009-10-19)Background The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region ... -
HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain
(Peer reviewed; Journal article, 2005-06-10)Background: The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the ... -
HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics
(Peer reviewed; Journal article, 2013-01-14)Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, ... -
Limited cross-border infections in patients newly diagnosed with HIV in Europe
(Peer reviewed; Journal article, 2013-04-03)Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections ... -
The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1
(Conference lecture, 2011-06-06) -
Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
(Peer reviewed; Journal article, 2009-05-20)Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from ... -
Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients
(Peer reviewed; Journal article, 2012-10-03)Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, ...