Blar i Bergen Open Research Archive på tidsskrift "eLIFE"

Viser treff 1-19 av 19

    • An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae 

      Kralt, Annemarie; Wojtynek, Matthias; Fischer, Jonas S.; Agote-Aran, Arantxa; Mancini, Roberta; Dultz, Elisa; Noor, Elad; Uliana, Federico; Tatarek-Nossol, Marianna; Antonin, Wolfram; Onishchenko, Evgeny; Medalia, Ohad; Weis, Karsten (Journal article; Peer reviewed, 2022)
      The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process ...

    • Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq 

      Vazquez, Sara E.; Mann, Sabrina A.; Bodansky, Aaron; Kung, Andrew F.; Quandt, Zoe; Ferré, Elise M N; Landegren, Nils; Eriksson, Daniel; Bastard, Paul; Zhang, Shen-Ying; Liu, Jamin; Mitchell, Anthea; Proekt, Irina; Yu, David; Mandel-Brehm, Caleigh; Wang, Chung-Yu; Miao, Brenda; Sowa, Gavin; Zorn, Kelsey; Chan, Alice Y.; Tagi, Veronica M.; Shimizu, Chisato; Tremoulet, Adriana; Lynch, Kara; Wilson, Michael R.; Kämpe, Olle; Dobbs, Kerry; Delmonte, Ottavia M.; Bacchetta, Rosa; Notarangelo, Luigi D.; Burns, Jane C.; Casanova, Jean-Laurent; Lionakis, Michail S.; Torgerson, Troy R.; Anderson, Mark S.; DeRisi, Joseph L. (Journal article; Peer reviewed, 2022)
      Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight ...

    • Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study 

      Hughes, Amanda M.; Sanderson, Eleanor; Morris, Tim; Ayorech, Ziada; Tesli, Martin Steen; Ask, Helga; Reichborn-Kjennerud, Ted; Andreassen, Ole; Magnus, Per Minor; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Davey Smith, George; Havdahl, Alexandra Karoline Saasen; Howe, Laura D.; Davies, Neil Martin (Journal article; Peer reviewed, 2022)
      Background: Higher BMI in childhood is associated with emotional and behavioural problems, but these associations may not be causal. Results of previous genetic studies imply causal effects but may reflect influence of ...

    • A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian 

      Chrysostomou, Eleni; Flici, Hakima; Gornik, Sebastian G.; Salinas-Saavedra, Miguel; Gahan, James Michael; McMahon, Emma T.; Thompson, Kerry; Hanley, Shirley; Kilcoyne, Michelle; Schnitzler, Christine E.; Gonzalez, Paul; Baxevanis, Andreas D.; Frank, Uri (Journal article; Peer reviewed, 2022)
      Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their ...

    • Demographic reconstruction from ancient DNA supports rapid extinction of the Great Auk 

      Thomas, Jessica E; Carvalho, Gary R.; James, Haile; Rawlence, Nicolas J.; Martin, Michael David; Ho, Simon Y.W.; Sigfússon, Arnór; Jósefsson, Vigfús A.; Frederiksen, Morten; Linnebjerg, Jannie F.; Castruita, Jose A. Samaniego; Niemann, Jonas; Sinding, Mikkel-Holger S.; Sandoval-Velasco, Marcela; Soares, André E.R.; Lacy, Robert; Barilaro, Christina; Best, Julia; Brandis, Dirk; Cavallo, Chiara; Elorza, Mikelo; Garrett, Kimball L; Groot, Maaike; Johansson, Friederike; Lifjeld, Jan Terje; Nilson, Göran; Serjeanston, Dale; Sweet, Paul; Fuller, Errol; Hufthammer, Anne Karin; Meldgaard, Morten; Fjeldså, Jon; Shapiro, Beth; Hofreiter, Michael; Gilbert, Marcus Thomas Pius; Knapp, Michael (Peer reviewed; Journal article, 2019-11-26)
      The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by ...

    • Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci 

      Han, Fan; Jamsandekar, Minal; Pettersson, Mats; Su, Leyi; Fuentes-Pardo, Angela P.; Davis, Brian W.; Bekkevold, Dorte; Berg, Florian; Casini, Michele; Dahle, Geir; Farrell, Edward D.; Folkvord, Arild; Andersson, Leif (Journal article; Peer reviewed, 2020)
      Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at ...

    • The effect of the COVID-19 pandemic on the gender gap in research productivity within academia 

      Lee, Kiran GL; Mennerat, Adele; Lukas, Dieter; Dugdale, Hannah L; Culina, Antica (Journal article; Peer reviewed, 2023)
      Using measures of research productivity to assess academic performance puts women at a disadvantage because gender roles and unconscious biases, operating both at home and in academia, can affect research productivity. The ...

    • Electric field causes volumetric changes in the human brain 

      Argyelan, Miklos; Oltedal, Leif; Deng, Zhi-De; Wade, Benjamin; Bikson, Marom; Joanlanne, Andrea; Sanghani, Sohag; Bartsch, Hauke; Cano, Marta; Dale, Anders M.; Dannlowski, Udo; Dols, Annemieke; Enneking, Verena; Espinoza, Randall; Kessler, Ute; Narr, Katherine L.; Ødegaard, Ketil Joachim; Oudega, Mardien L.; Redlich, Ronny; Stek, Max L.; Takamiya, Akihiro; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Pujol, Jesus; Tendolkar, Indira; van Eijndhoven, Philip; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher (Peer reviewed; Journal article, 2019)
      Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used ...

    • Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network 

      Torres Cleuren, Yamila Nicole; Ewe, Chee Kiang; Chipman, Kyle C; Mears, Emily R; Wood, Cricket G; Al-Alami, Coco Emma Alma; Alcorn, Melissa R; Turner, Thomas L; Joshi, Pradeep M; Snell, Russell G; Rothman, Joel H (Peer reviewed; Journal article, 2019-08-15)
      Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, ...

    • Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis 

      Gucek, Alenka; Gandasi, Nikhil R.; Omar-Hmeadi, Muhmmad; Bakke, Marit; Doskeland, Stein Ove; Tengholm, Anders; Barg, Sebastian (Peer reviewed; Journal article, 2019-05-20)
      Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ...

    • Heat shock factor 1 (Hsf1) cooperates with estrogen receptor α (erα) in the regulation of estrogen action in breast cancer cells 

      Vydra, Natalia; Janus, Patryk; Kuś, Paweł; Stokowy, Tomasz; Mrowiec, Katarzyna; Toma-Jonik, Agnieszka; Krzywon, Aleksandra; Cortez, Alexander Jorge; Wojtaś, Bartosz; Gielniewski, Bartłomiej; Jaksik, Roman; Kimmel, Marek; Widłak, Wiesława (Journal article; Peer reviewed, 2021)
      Heat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress, was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an HSF1 deficiency may decrease ERα ...

    • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight 

      Iurilli, Maria Laura Caminia; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino Antonio Moura; Chirita-Emandi, Adela; Hayes, Alison J; Ikeda, Nayu; Jackson, Rod T.; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Saidi, Olfa; Sebert, Sylvain; Sorić, Maroje; Starc, Gregor; Gregg, Edward W.; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdrakhmanova, Shynar; Ghaffar, Suhaila Abdul; Rahim, Hanan Abdul; Abu-Rmeileh, Niveen M.; Garba, Jamila Abubakar; Acosta-Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmad, Mohamad Hasnan; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Hassan, Soheir; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grethe S.; Torheim, Liv Elin; Wilsgaard, Tom (Journal article; Peer reviewed, 2021)
      From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated ...

    • Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication 

      Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge; Bergersen, Linda H.; Esbensen, Qin Ying; Sverkeli, Lars Jansen; Ziegler, Mathias; Attramadal, Håvard; Halvorsen, Bente; Aukrust, Pål; Yndestad, Arne (Journal article; Peer reviewed, 2021)
      Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ...

    • Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate 

      Feng, Chungang; Pettersson, Mats; Lamichhaney, Sangeet; Rubin, Carl-Johan; Rafati, Nima; Casini, Michele; Folkvord, Arild; Andersson, Leif (Peer reviewed; Journal article, 2017-06-30)
      The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (π = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation ...

    • Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution 

      Marti Solans, Josep; Børve, Aina; Bump, Paul; Hejnol, Andreas; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2023)
      Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, ...

    • Rapid genome editing by CRISPR-Cas9-POLD3 fusion 

      Reint, Ganna; Li, Zhuokun; Labun, Kornel; Keskitalo, Salla; Soppa, Inkeri; Mamia, Katariina Aino Inkeri; Tolo, Eero; Szymanska, Monika; Meza-Zepeda, Leonardo A.; Lorenz, Susanne; Cieslar-Pobuda, Artur Grzegorz; Hu, Xian; Bodin, Diana L; Staerk, Judith; Valen, Eivind Dale; Schmierer, Bernhard; Varjosalo, Markku; Taipale, Jussi; Haapaniemi, Emma Maria (Journal article; Peer reviewed, 2021)
      Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the ...

    • Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells 

      Bernadskaya, Yelena Y.; Yue, Haicen; Copos, Calina; Christiaen, Lionel; Mogilner, Alex (Journal article; Peer reviewed, 2021)
      Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale ...

    • Transcriptional adaptation in caenorhabditis elegans 

      Serobyan, Vahan; Kontarakis, Zacharias; El-Brolosy, Mohamed A.; Welker, Jordan M.; Tolstenkov, Oleg; Saadeldein, Amr M.; Retzer, Nicholas; Gottschalk, Alexander; Wehman, Ann M; Stainier, Didier YR (Journal article; Peer reviewed, 2020-01)
      Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed ...

    • The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution 

      Hausen, Harald; Döring, Clemens; Kumar, Suman; Tumu, Sharat Chandra; Kourtesis, Ioannis (Journal article; Peer reviewed, 2020)
      Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ...