Blar i Bergen Open Research Archive på forfatter "Åsrud, Kathrine Sivertsen"
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Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions
Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara; Karlsen, Tine Veronica; Rygh, Cecilie Brekke; Curry, Fitz-Roy; Bakke, Marit; Reed, Rolf K.; Tenstad, Olav; Døskeland, Stein Ove (Journal article; Peer reviewed, 2020)Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ... -
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Døskeland, Stein Ove; Selheim, Frode (Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ... -
Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling
Edland, Fridtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Åsrud, Kathrine Sivertsen; Hoivik, Erling A; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, L; Kristiansen, K.; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K (Peer reviewed; Journal article, 2016-11-28)Background: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This ... -
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ... -
Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways
Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen; Høivik, Erling Andre; Ruas, Jorge L.; Poellinger, Lorenz; Bakke, Marit (Peer reviewed; Journal article, 2014-03-11)Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear. ...