• Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes 

      Jain, Ruchi; Özgümüs, Türküler; Jensen, Troels Mygind; du Plessis, Elsa; Keindl, Magdalena; Møller, Cathrine Laustrup; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Jessen, Leon Eyrich; Forsblom, Carol; Haukka, Jani K.; Groop, Per-Henrik; Rossing, Peter; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Al-Majdoub, Mahmoud; Nilsson, Peter M.; Taskinen, Marja-Riitta; Ferrannini, Ele; Spégel, Peter; Berg, Tore Julsrud; Lyssenko, Valeriya (Journal article; Peer reviewed, 2020)
      Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma ...
    • Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes 

      Fedotkina, Olena; Jain, Ruchi; Prasad, Rashmi B.; Luk, Andrea; García-Ramírez, Marta; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Kravchenko, Victor; Jain, Deepak; Vaag, Allan; Chan, Juliana; Khalangot, Mykola D.; Hernández, Cristina; Nilsson, Peter M.; Simo, Rafael; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2022-05-05)
      Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ...
    • Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine 

      Fedotkina, Olena; Sulaieva, Oksana; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Ahlqvist, Emma; Asplund, Olof; Groop, Leif; Nilsson, Peter M.; Lyssenko, Valeriya (Journal article; Peer reviewed, 2021)
      Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ...
    • Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents 

      Ertesvåg, Nina Urke; Iversen, Arild; Blomberg, Bjørn; Özgümüs, Türküler; Rijal, Pramila; Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Langeland, Nina; Haug, Kjell; Sandnes, Helene Heitmann; Mohn, Kristin Greve-Isdahl; Olofsson, Jan Stefan; Sævik, Marianne; Brokstad, Christopher James; Kuwelker, Kanika; Heienberg, Kristin (Journal article; Peer reviewed, 2023)
      Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ...
    • Prevalence and predictors of post-COVID-19 symptoms in general practice - a registry-based nationwide study 

      Hetlevik, Øystein; Wensaas, Knut-Arne; Baste, Valborg; Emberland, Knut Erik; Özgümüs, Türküler; Håberg, Siri Eldevik; Rørtveit, Guri (Journal article; Peer reviewed, 2023)
      Background With Norwegian national registry data, we assessed the prevalence of post-COVID-19 symptoms at least 3 months after confirmed infection, and whether sociodemographic factors and pre-pandemic health problems were ...
    • Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study 

      Özgümüs, Türküler; Sulaieva, Oksana; Jessen, Leon E.; Jain, Ruchi; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Stokowy, Tomasz; Nilsson, Peter M.; Lyssenko, Valeriya (Journal article; Peer reviewed, 2021)
      Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia ...
    • Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells 

      Özgümüs, Türküler; Sulaieva, Oksana; Jain, Ruchi; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2021)
      Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light ...
    • Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study 

      Fjelltveit, Elisabeth Berg; Blomberg, Bjørn; Kuwelker, Kanika; Zhou, Fan; Onyango, Therese Bredholt; Brokstad, Karl Albert; Elyanow, Rebecca G; Kaplan, Ian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2022)
      Background The burden and duration of persistent symptoms after nonsevere coronavirus disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection symptom trajectories in home-isolated COVID-19 cases ...