• Actigraphic registration of motor activity reveals a more structured behavioural pattern in schizophrenia than in major depression 

      Berle, Jan Øystein; Hauge, Erik R.; Ødegaard, Ketil Joachim; Holsten, Fred; Fasmer, Ole Bernt (Peer reviewed; Journal article, 2010-05-27)
      Background: Disturbances in motor activity pattern are seen in both schizophrenia and depression. However, this activity has rarely been studied objectively. The purpose of the present study has been to study the complexity ...
    • Adult attention deficit hyperactivity disorder is associated with asthma 

      Fasmer, Ole Bernt; Halmøy, Anne; Eagan, Tomas Mikal; Ødegaard, Ketil Joachim; Haavik, Jan (Peer reviewed; Journal article, 2011-08-07)
      Background: Attention deficit hyperactivity disorder (ADHD) is increasingly recognized as a common disorder not only in children, but also in the adult population. Similarly, asthma also has a substantial prevalence among ...
    • Adult attention deficit hyperactivity disorder is associated with migraine headaches 

      Fasmer, Ole Bernt; Halmøy, Anne; Ødegaard, Ketil Joachim; Haavik, Jan (Peer reviewed; Journal article, 2011-03-11)
      Attention deficit hyperactivity disorder (ADHD) is now recognized as a common disorder both in child and adult psychiatry. Adult patients with a diagnosis of ADHD (n = 572) and community controls (n = 675) responded to ...
    • Brain changes induced by electroconvulsive therapy are broadly distributed 

      Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; Wade, Benjamin; Vandenbulcke, Mathieu; Urretavizcaya, Mikel; Tendolkar, Indira; Takamiya, Akihiro; Stek, Max L.; Soriano-Mas, Carles; Redlich, Ronny; Paulson, Olaf B.; Oudega, Mardien L.; Opel, Nils; Nordanskog, Pia; Kishimoto, Taishiro; Kämpe, Robin; Jørgensen, Anders; Hanson, Lars G.; Hamilton, J. Paul; Espinoza, Randall; Emsell, Louise; van Eijndhoven, Philip; Dols, Annemieke; Dannlowski, Udo; Cardoner, Narcis; Bouckaert, Filip; Anand, Amit; Bartsch, Hauke; Kessler, Ute; Ødegaard, Ketil Joachim; Dale, Anders; Oltedal, Leif (Peer reviewed; Journal article, 2020-03-01)
      Background Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we ...
    • Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder 

      McCarthy, Michael J.; Stautland, Andrea; Jakobsen, Petter; Ødegaard, Ketil Joachim; Andreassen, Ole Andreas; Djurovic, Srdjan; Morken, Gunnar; Schøyen, Helle Kristine; McInnis, Melvin G.; Alda, Martin; Gage, Fred H.; Calabrese, Joseph R.; Zandi, Peter P.; Nievergelt, Caroline M.; Shilling, Paul D.; Kelsoe, John R. (Peer reviewed; Journal article, 2019)
      Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood ...
    • Cyclothymic temperament: Associations with ADHD, other psychopathology, and medical morbidity in the general population 

      Syrstad, Vigdis Elin Giæver; Ødegaard, Ketil Joachim; Fasmer, Ole Bernt; Halmøy, Anne; Haavik, Jan; Dilsaver, Stephen C.; Gjestad, Rolf (Peer reviewed; Journal article, 2020)
      Background: Cyclothymic temperament (CT) is an affective disposition often preceding bipolar disorder (BD), and is the most common affective temperament in patients with BD. In depressed patients, CT is a predictor for ...
    • Diurnal variation of motor activity in adult ADHD patients analyzed with methods from graph theory 

      Fasmer, Ole Bernt; Fasmer, Erlend Eindride; Mjeldheim, Kristin; Førland, Wenche; Syrstad, Vigdis Elin Giæver; Jakobsen, Petter; Berle, Jan Øystein; Henriksen, Tone Elise Gjøtterud; Sepasdar, Zahra; Hauge, Erik Rønneberg; Ødegaard, Ketil Joachim (Journal article; Peer reviewed, 2020-11)
      Attention-deficit /hyperactivity disorder (ADHD) is a common neurodevelopmental syndrome characterized by age-inappropriate levels of motor activity, impulsivity and attention. The aim of the present study was to study ...
    • The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites 

      Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute (Peer reviewed; Journal article, 2019-05-31)
      Background: Prior studies suggest that activation of the tryptophan catabolism via the kynurenine pathway by proinflammatory cytokines may be involved in the pathophysiology of depression. Electroconvulsive therapy (ECT) ...
    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...
    • Electric field causes volumetric changes in the human brain 

      Argyelan, Miklos; Oltedal, Leif; Deng, Zhi-De; Wade, Benjamin; Bikson, Marom; Joanlanne, Andrea; Sanghani, Sohag; Bartsch, Hauke; Cano, Marta; Dale, Anders M.; Dannlowski, Udo; Dols, Annemieke; Enneking, Verena; Espinoza, Randall; Kessler, Ute; Narr, Katherine L.; Ødegaard, Ketil Joachim; Oudega, Mardien L.; Redlich, Ronny; Stek, Max L.; Takamiya, Akihiro; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Pujol, Jesus; Tendolkar, Indira; van Eijndhoven, Philip; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher (Peer reviewed; Journal article, 2019)
      Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used ...
    • Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder 

      Jacobsen, Kaya Kvarme; Nievergelt, Caroline M.; Zayats, Tetyana; Greenwood, Tifany A.; Anttila, Verneri; Akiskal, Hagop Souren; Haavik, Jan; Fasmer, Ole Bernt; Kelsoe, John R.; Johansson, Stefan; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-10-12)
      Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ...
    • Linear and non-linear analyses of Conner’s Continuous Performance Test-II discriminate adult patients with attention deficit hyperactivity disorder from patients with mood and anxiety disorders 

      Fasmer, Ole Bernt; Mjeldheim, Kristin; Førland, Wenche; Hansen, Anita Lill; Syrstad, Vigdis Elin Giæver; Ødegaard, Ketil Joachim; Berle, Jan Øystein (Peer reviewed; Journal article, 2016-08-11)
      Background: Attention Deficit Hyperactivity Disorder (ADHD) is a heterogeneous disorder. Therefore it is important to look for factors that can contribute to better diagnosis and classification of these patients. The aims ...
    • A longitudinal 5-year follow-up study of cognitive function after first episode major depressive disorder: Exploring state, scar and trait effects 

      Ronold, Eivind Haga; Schmid, Marit Therese; Ødegaard, Ketil Joachim; Hammar, Åsa (Journal article; Peer reviewed, 2020)
      Major depression (MDD) is associated with cognitive deficits in processing speed and executive function (EF) following first episode (FE). It is unclear whether deficits are state or trait related. Studies following FE MDD ...
    • A Naturalistic Study of the Effect of Acupuncture on Heart-Rate Variability 

      Fasmer, Ole Bernt; Liao, Hanbo; Huang, Yong; Berle, Jan Øystein; Wu, Junxian; Ødegaard, Ketil Joachim; Wik, Gustav; Zhang, Zhangjin (Peer reviewed; Journal article, 2012-02)
      Objectives: To study the effect of acupuncture on heart rate variability (HRV) by using linear and non-linear methods of analysis. Methods: 40 patients were recruited consecutively, including patients with insomnia, ...
    • Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression 

      Kessler, Ute; Schøyen, Helle Kristine; Andreassen, Ole Andreas; Eide, Geir Egil; Hammar, Åsa; Malt, Ulrik F.; Ødegaard, Ketil Joachim; Morken, Gunnar; Sundet, Kjetil; Vaaler, Arne E. (Peer reviewed; Journal article, 2013-04-04)
      Background: The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD ...
    • Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression 

      Kessler, Ute; Schøyen, Helle Kristine; Andreassen, Ole Andreas; Eide, Geir Egil; Hammar, Åsa; Malt, Ulrik Fredrik; Ødegaard, Ketil Joachim; Morken, Gunnar; Sundet, Kjetil Søren; Vaaler, Arne Einar (Peer reviewed; Journal article, 2013-04-04)
      Background The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD ...
    • Nonlinear Analysis of Motor Activity Shows Differences between Schizophrenia and Depression: A Study Using Fourier Analysis and Sample Entropy 

      Hauge, Erik R.; Berle, Jan Øystein; Ødegaard, Ketil Joachim; Holsten, Fred; Fasmer, Ole Bernt (Peer reviewed; Journal article, 2011-01-28)
      The purpose of this study has been to describe motor activity data obtained by using wrist-worn actigraphs in patients with schizophrenia and major depression by the use of linear and non-linear methods of analysis. Different ...
    • The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample 

      Ødegaard, Ketil Joachim; Alda, Martin; Anand, Anit; Andreassen, Ole Andreas; Balaraman, Yokesh; Berrettini, Wade H.; Bhattacharjee, Abesh; Brennand, Kristen J.; Burdick, Katherine E.; Calabrese, Joseph R.; Calkin, Cynthia V.; Claasen, Ana; Coryell, William H.; Craig, David; DeModena, Anna; Frye, Mark A.; Gage, Fred H.; Gao, Keming; Garnham, Julie; Gershon, Elliot; Jakobsen, Petter; Leckband, Susan G.; McCarthy, Michael J.; McInnis, Melvin G.; Maihofer, Adam X.; Mertens, Jerome; Morken, Gunnar; Nievergelt, Caroline M.; Nurnberger, John I.; Pham, Son; Schøyen, Helle Kristine; Shekhtman, Tatyana; Shilling, Paul D.; Szelinger, Szabolcs; Tarwater, Bruce; Yao, Jun; Zandi, Peter P.; Kelsoe, John R. (Peer reviewed; Journal article, 2016-05-05)
      Background: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization ...
    • Prevalence and characteristics of depressive disorders in type 1 diabetes 

      Berge, Line Iden; Riise, Trond; Hundal, Øivind; Ødegaard, Ketil Joachim; Dilsaver, Steven; Lund, Anders (Peer reviewed; Journal article, 2013-12-19)
      Background: Persons with diabetes and depression have increased risk of complications and increased mortality. We aimed to investigate the prevalence, clinical characteristics and impact with regard to glycosylated haemoglobin ...
    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...