• Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison’s Disease: A Randomized Clinical Trial 

      Øksnes, Marianne; Björnsdottir, Sigridur; Isaksson, Magnus; Methlie, Paal; Carlsen, Siri; Nilsen, Roy Miodini; Broman, Jan-Erik; Triebner, Kai; Kämpe, Olle; Hulting, Anna-Lena; Bensing, Sophie; Husebye, Eystein Sverre; Løvås, Kristian (Peer reviewed; Journal article, 2014)
      Context: Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison’s disease. Objective: The objective ...
    • Development of a Disease-Specific Quality of Life Questionnaire in Addison’s Disease 

      Løvås, Kristian; Curran, Suzanne; Øksnes, Marianne; Husebye, Eystein Sverre; Huppert, Felicia A.; Chatterjee, V. Krishna K. (Peer reviewed; Journal article, 2010-02)
      Context: Patients with Addison’s disease reproducibly self-report impairment in specific dimensions of general well-being questionnaires, suggesting particular deficiencies in health-related quality-of-life (HRQoL). ...
    • Glucocorticoid Treatment and Quality of Life in Addison’s disease 

      Øksnes, Marianne (Doctoral thesis, 2014-06-06)
      Addison’s disease (AD) is rare and result in lack of the adrenal hormones cortisol, aldosterone and adrenal androgens. Despite conventional oral replacement therapy, mortality is increased and Health-Related Quality-of-life ...
    • Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease 

      Sævik, Åse Bjorvatn; Wolff, Anette Susanne Bøe; Björnsdottir, Sigridur; Simunkova, Katerina; Hynne, Martha Schei; Dolan, David William Peter; Bratland, Eirik; Knappskog, Per M; Methlie, Paal; Carlsen, Siri; Isaksson, Magnus; Bensing, Sophie; Kämpe, Olof; Husebye, Eystein S; Løvås, Kristian; Øksnes, Marianne (Journal article; Peer reviewed, 2021)
      Background No reliable biomarkers exist to guide glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD), leading to overtreatment with alarming and persistent side effects or undertreatment, which ...
    • Primary ovarian insufficiency in women with Addison's disease 

      Vogt, Elinor Margrethe Chelsom; Breivik, Lars Ertesvåg; Røyrvik, Ellen Christine; Grytaas, Marianne; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Peer reviewed, 2021)
      Context Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison’s disease (AAD) than in the general population, but their clinical ...
    • Quality of Life in European Patients with Addison’s Disease: Validity of the Disease-Specific Questionnaire AddiQoL 

      Øksnes, Marianne; Bensing, Sophie; Hulting, Anna-Lena; Kämpe, Olle; Hackemann, Annika; Meyer, Gesine; Badenhoop, Klaus; Betterle, Corrado; Parolo, Anna; Giordano, Roberta; Falorni, Alberto; Papierska, Lucyna; Jeske, Wojciech; Kasperlik-Zaluska, Anna A.; Chatterjee, V. Krishna K.; Husebye, Eystein Sverre; Løvås, Kristian (Peer reviewed; Journal article, 2012-02)
      Context: Patients with Addison’s disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients. ...
    • Residual Corticosteroid Production in Autoimmune Addison Disease 

      Sævik, Åse Bjorvatn; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Høybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Bensing, Sophie; Øksnes, Marianne (Journal article; Peer reviewed, 2020)
      Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual ...
    • Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency 

      Didriksen, Nora Møller; Sævik, Åse Bjorvatn; Sortland, Linn Solveig; Øksnes, Marianne; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2021)
      Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ...