• The association between aspects of carer distress and time until nursing home admission in persons with Alzheimer’s disease and dementia with Lewy bodies 

      Terum, Toril Marie; Rongve, Arvid; Testad, Ingelin; Aarsland, Dag; Svendsboe, Ellen J; Andersen, John Roger (Journal article; Peer reviewed, 2020)
      Objective: The aim of this study was to explore the association between specific aspects of carer distress and time until nursing home admission (NHA) in people with mild dementia. Design: Prospective cohort ...
    • The association between specific neuropsychiatric disturbances in people with Alzheimer's disease and dementia with Lewy bodies and carer distress 

      Terum, Toril Marie; Testad, Ingelin; Rongve, Arvid; Aarsland, Dag; Svendsboe, Ellen J; Andersen, John Roger (Peer reviewed; Journal article, 2019)
      Objective: Neuropsychiatric symptoms (NPSs) are identified as important care‐recipient variables in terms of the impact on carer distress. The aim of this study was to determine whether specific neuropsychiatric disturbances ...
    • Combinatory microRNA serum signatures as classifiers of Parkinson's disease 

      Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Peer reviewed; Journal article, 2019)
      Introduction: As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will ...
    • COSMOS-improving the quality of life in nursing home patients: Protocol for an effectiveness-implementation cluster randomized clinical hybrid trial 

      Husebø, Bettina; Flo, Elisabeth; Aarsland, Dag; Selbæk, Geir; Testad, Ingelin; Gulla, Christine; Aasmul, Irene; Ballard, Clive (Peer reviewed; Journal article, 2015-09-15)
      Background: Nursing home patients have complex mental and physical health problems, disabilities and social needs, combined with widespread prescription of psychotropic drugs. Preservation of their quality of life is an ...
    • Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study 

      Bergland, Anne Katrine; Sønnesyn, Hogne; Dalen, Ingvild; Rodriguez-Mateos, Ana; Berge, Rolf Kristian; Melvær, Giil Lasse; Rajendran, Lawrence; Siow, Richard; Tassotti, Michele; Larsen, Alf Inge; Aarsland, Dag (Peer reviewed; Journal article, 2019-06-11)
      Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ...
    • Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial 

      Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)
      Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ...
    • Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM) 

      Erdal, Ane; Flo, Elisabeth; Aarsland, Dag; Ballard, Clive; Slettebø, Dagrun Daltveit; Husebø, Bettina (Peer reviewed; Journal article, 2018-06)
      Background Chronic pain and depression often co-occur, and pain may exacerbate depression in people with dementia. Objective The objective of this study was to assess the efficacy and safety of analgesic treatment for ...
    • Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial 

      Husebø, Bettina Sandgathe; Ballard, Clive; Fritze, Friederike; Sandvik, Reidun Karin; Aarsland, Dag (Peer reviewed; Journal article, 2014-08)
      Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact ...
    • Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease 

      Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Peer reviewed; Journal article, 2019-10-22)
      Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ...
    • Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations 

      Olafsson, S.; Stridh, P.; Bos, Steffan Daniel; Ingason, Andrés; Euesden, J; Sulem, Patrick; Thorleifsson, Gudmar; Gustafsson, O; Geirsson, AJ; Jóhannesson, Ari J.; Thorsson, AV; Ludviksson, BR; Sigurgeirsson, Bardur; Jonasson, JG; Olafsson, E; Kristjansdottir, H; Olafsson, JH; Orvar, KB; Benediktsson, Rafn; Bjarnason, Ragnar; Kristjansdottir, Sjofn; Gislason, Thorarin; Valdimarsson, T; Mikaelsdottir, E; Sigurdsson, S; Jonsson, S; Rafnar, Thorunn; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Knudsen, Gun Peggy S.; Celius, Elisabeth Gulowsen; Myhr, Kjell-Morten; Gröndal, Gerdur; Steinsson, K; Valdimarsson, Helgi; Bjornsson, Sigurdur; Bjornsdottir, US; Bjornsson, Einar S.; Nilsson, B; Andreassen, Ole Andreas; Alfredsson, Lars; Hillert, Jan; Kockum, Ingrid; Másson, Gísli; Thorsteinssdottir, U; Gudbjartsson, Daniel F.; Stefansson, H; Hjaltason, H; Harbo, Hanne Flinstad; Olsson, T; Jonsdottir, I; Stefansson, K (Peer reviewed; Journal article, 2017)
      A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple ...
    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-05-07)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • High prevalence of orthostatic hypotension in mild dementia 

      Sønnesyn, Hogne; Nilsen, Dennis W. T.; Rongve, Arvid; Nore, Sabine; Ballard, Clive; Tysnes, Ole-Bjørn; Aarsland, Dag (Peer reviewed; Journal article, 2009-11)
      Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild ...
    • Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: A cluster randomized trial 

      Sandvik, Reidun Karin; Selbæk, Geir; Seifert, Reinhard; Aarsland, Dag; Ballard, Clive; Corbett, Anne; Husebø, Bettina Sandgathe (Peer reviewed; Journal article, 2014-05-13)
      Background: Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome. Methods: Three hundred fifty-two ...
    • Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia 

      Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019)
      Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ...
    • Large-scale resting state network correlates of cognitive impairment in Parkinson’s disease and related dopaminergic deficits 

      Lebedev, Alexander; Westman, Eric; Simmons, Andrew; Lebedeva, Aleksandra; Siepel, Françoise J.; Pereira, Joana B.; Aarsland, Dag (Peer reviewed; Journal article, 2014-04-03)
      Cognitive impairment is a common non-motor feature of Parkinson’s disease (PD). Understanding the neural mechanisms of this deficit is crucial for the development of efficient methods for treatment monitoring and augmentation ...
    • A longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer’s disease 

      Brønnick, Kolbjørn; Aarsland, Dag; Rongve, Arvid; Breitve, Monica Haraldseid; Hynninen, Minna J.; Chwiszczuk, Luiza J.; Auestad, Bjørn H. (Peer reviewed; Journal article, 2016-01-26)
      Background: Anxiety in dementia is common but not well studied. We studied the associations of anxiety longitudinally in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: In total, 194 patients with a ...
    • A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer`s Disease 

      Breitve, Monica Haraldseid; Chwiszczuk, Luiza; Hynninen, Kia Minna; Brønnick, Kolbjørn Selvåg; Auestad, Bjørn Henrik; Aarsland, Dag; Rongve, Arvid (Peer reviewed; Journal article, 2018-03-06)
      Introduction: There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have ...
    • Male caregivers to persons diagnosed with Lewy Body Dementia have higher stress level than caregiver to persons diagnosed with Alzheimers Dementia 

      Svendsbø, Ellen J; Terum, Toril; Testad, Ingelin; Aarsland, Dag; Rongve, Arvid (Conference object, 2015)
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-12-27)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...
    • Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia 

      Sønnesyn, Hogne; Dalen, Ingvild; Aarsland, Dag (Peer reviewed; Journal article, 2014)
      Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia. Methods: Referrals to outpatient clinics specialising in old age psychiatry and ...