• Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors 

      Aasen, Synnøve Nymark; Parajuli, Himalaya; Hoang, Tuyen; Feng, Zichao; Stokke, Krister; Wang, Jiwei; Roy, Kislay; Bjerkvig, Rolf; Knappskog, Stian; Thorsen, Frits (Peer reviewed; Journal article, 2019-08-29)
      Malignant melanoma is the most aggressive type of skin cancer and is closely associated with the development of brain metastases. Despite aggressive treatment, the prognosis has traditionally been poor, necessitating ...
    • Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis 

      Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)
      Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ...
    • A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines 

      Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf; Pánek, Jiří; Hrubý, Martin; Štěpánek, Petr; Spriet, Endy; Jirák, Daniel; Skaftnesmo, Kai Ove; Thorsen, Frits (Peer reviewed; Journal article, 2015-09-08)
      To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ...
    • Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization 

      Zhang, Xin; Ding, Kaikai; Ji, Jianxiong; Parajuli, Himalaya; Aasen, Synnøve Nymark; Espedal, Heidi; Huang, Bin; Chen, Anjing; Wang, Jian; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2020)
      Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain ...
    • Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe 

      Aasen, Synnøve Nymark (Master thesis, 2014-06-05)
      The incidence of malignant melanoma has increased steadily during the last decades. Large portions of individuals with this particular skin cancer develop multiple brain metastases, which is associated with a particular ...