Browsing Bergen Open Research Archive by Author "Abadpour, Shadab"

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In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism

Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon; Vethe, Heidrun; Bjørlykke, Yngvild; Abadpour, Shadab; Paulo, Joao; Scholz, Hanne; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)

Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ...
In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress

Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun; Abadpour, Shadab; Mathisen, Andreas; Paulo, Joao A.; Scholz, Hanne; Ræder, Helge; Chera, Simona (Peer reviewed; Journal article, 2020)

Aim: The loss of insulin‐secreting β‐cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into ...