Browsing Bergen Open Research Archive by Author "Aesoy, Reidun"
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Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria
Fewer, David P.; Jokela, Jouni; Heinilä, Lassi; Aesoy, Reidun; Sivonen, Kaarina; Galica, Tomáš; Hrouzek, Pavel; Herfindal, Lars (Journal article; Peer reviewed, 2021)Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty ... -
Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice
Aesoy, Reidun; Muwonge, Haruna; Sivertsen Åsrud, Kathrine; Sabir, Misbah; Witsø, Solveig Lund; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Høivik, Erling Andre; Doskeland, Stein Ove; Bakke, Marit (Journal article; Peer reviewed, 2018-07-26)Previous studies demonstrate essential roles for the exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2; here collectively referred to as Epac) in the brain. In the hippocampus, Epac contributes to the ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun; Diaz, Andrea Estefania Carpinteyro; Herfindal, Lars; Fossen, Torgils (Journal article; Peer reviewed, 2022)Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ...