Browsing Bergen Open Research Archive by Author "Afset, Jan Egil"

Now showing items 1-7 of 7

    • The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants 

      Ianevski, Aleksandr; Frøysa, Irene Trøen; Lysvand, Hilde; Calitz, Carlemi; Smura, Teemu; Nilsen, Hans-Johnny; Høyer, Erling; Afset, Jan Egil; Sridhar, Adithya; Wolthers, Katja C.; Zusinaite, Eva; Tenson, Tanel; Kurg, Reet; Oksenych, Valentyn; Galabov, Angel S.; Stoyanova, Adelina; Bjørås, Magnar; Kaynov, Denis (Journal article; Peer reviewed, 2024)
      Enteroviruses are a significant global health concern, causing a spectrum of diseases from the common cold to more severe conditions like hand-foot-and-mouth disease, meningitis, myocarditis, pancreatitis, and poliomyelitis. ...

    • Cryptosporidium species and subtypes in Norway: predominance of C. parvum and emergence of C. mortiferum 

      Tipu, Jahid Hasan; Sivertsen, Audun; Afset, Jan Egil; Sandven, Lars; Brekke, Hanne; Lund, Hilde Marie; Elburg, Linnea Sofie; Gaustad, Peter; Lier, Tore; Tverelv, Liv Reidun; Johansen, Øystein Haarklau; Robertson, Lucy; Hanevik, Kurt (Journal article; Peer reviewed, 2024)
      PCR-based diagnostics has revealed the previously largely unknown Cryptosporidium transmission and infections in high-income countries. This study aimed to determine domestic and imported subtypes of Cryptosporidium species ...

    • Detailed stratified GWAS analysis for severe COVID-19 in four European populations 

      Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Journal article; Peer reviewed, 2022)
      Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ...

    • High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting 

      Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Journal article; Peer reviewed, 2022)
      Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ...

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Risk of death in Klebsiella pneumoniae bloodstream infections is associated with specific phylogenetic lineages 

      Fostervold, Aasmund; Raffelsberger, Niclas Peter; Hetland, Marit; Bakksjø, Ragna-Johanne; Bernhoff, Eva; Samuelsen, Ørjan; Sundsfjord, Arnfinn Ståle; Afset, Jan Egil; Berntsen, Christopher Friis; Bævre-Jensen, Roar Magne; Ebbesen, Marit Helen; Gammelsrud, Karianne Wiger; Guleng, Anja D.; Handal, Nina; Jakovljev, Aleksandra; Johal, Simreen Kaur; Marvik, Åshild; Natvik, Ane Kristine; Sandnes, Rolf-Arne; Tofteland, Ståle; Bjørnholt, Jørgen; Löhr, Iren Høyland (Journal article; Peer reviewed, 2024)
      Background Klebsiella pneumoniae species complex (KpSC) bloodstream infections (BSIs) are associated with considerable morbidity and mortality, particularly in elderly and multimorbid patients. Multidrug-resistant (MDR) ...

    • Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort 

      Grønseth, Stine; Rogne, Tormod; Heggelund, Lars; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2023)
      Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ...