Blar i Bergen Open Research Archive på forfatter "Ahmed, Aymen B"
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Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial
Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Hellem, Sølve; Rojewski, Markus; Gjengedal, Harald; Yassin, Mohammed Ahmed Alamin Yousif; Feng, Xin; Skaale, Siren G; Berge, Trond Inge; Rosén, Annika; Shi, Xieqi; Ahmed, Aymen B; Gjertsen, Bjørn Tore; Schrezenmeier, Hubert; Layrolle, Pierre (Journal article; Peer reviewed, 2018)Background Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone ... -
Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation – a study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients
Rundgren, Ida Marie; Ersvær, Elisabeth; Ahmed, Aymen B; Ryningen, Anita; Bruserud, Øystein (Journal article, 2019)Background Induction therapy of multiple myeloma patients prior to autologous stem cell transplantation has changed from conventional chemotherapy to treatment based on proteasome inhibitors or immunomodulatory drugs. We ... -
IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy
Tvedt, Tor Henrik Anderson; Rose-John, Stefan; Tsykunova, Galina; Ahmed, Aymen B; Gedde-Dahl, Tobias; Ersvær, Elisabeth; Bruserud, Øystein (Journal article; Peer reviewed, 2022)Graft-versus-host disease (GVHD), one of the most common and serious complications after allogeneic stem cell transplantation, is mediated by allocative T cells. IL-6 mediates both pro- and anti-inflammatory effects and ... -
Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses
Tvedt, Tor Henrik Anderson; Melve, Guro Kristin; Tsykunova, Galina; Ahmed, Aymen B; Brenner, Annette; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-22)Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ... -
Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor
Melve, Guro Kristin; Ersvær, Elisabeth; Akkøk, Cigdem Ahaein; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Bruserud, Øystein (Peer reviewed; Journal article, 2016-07-19)Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ... -
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome
Reikvam, Håkon; Grønningsæter, Ida-Sofie; Ahmed, Aymen B; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-12)Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ... -
A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies.
Rundgren, Ida Marie; Ersvær, Elisabeth; Ahmed, Aymen B; Bruserud, Øystein; Ryningen, Anita (Journal article; Peer reviewed, 2020)Background and Objectives: Autologous and allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies, and monocytes are probably involved in hematological reconstitution as well ... -
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation
Tvedt, Tor Henrik Anderson; Hovland, Randi; Tsykunova, Galina; Ahmed, Aymen B; Gedde-Dahl, Thobias; Bruserud, Øyvind (Peer reviewed; Journal article, 2018-07)Interleukin (IL)‐6 is an important regulator of immunity and inflammation in many diseases. Single nucleotide polymorphisms (SNPs) in the IL‐6 gene influence outcome after allogeneic stem cell transplantation (ASCT), but ... -
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Ahmed, Aymen B; Vintermyr, Olav Karsten; Hervig, Tor Audun; Guttormsen, Anne Berit; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused ... -
Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data
Rojewski, Markus Thomas; Lofti, Ramin; Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Veronesi, Elena; Ahmed, Aymen B; Wiesneth, Markus; Körper, Sixten; Sensebé, Luc; Layrolle, Pierre; Hellem, Sølve; Schrezenmeier, Hubert (Journal article; Peer reviewed, 2019)Background Many data are available on expansion protocols for mesenchymal stromal cells (MSCs) for both experimental settings and manufacturing for clinical trials. However, there is a lack of information on translation ...