Browsing Bergen Open Research Archive by Author "Akslen, Lars Andreas"

Now showing items 1-20 of 27

    • Age-Related Clusters and Favorable Immune Phenotypes in Breast Cancer of the Young Patients 

      Ingebriktsen, Lise Martine; Svanøe, Amalie Abrahamsen; Sæle, Anna Kristine Myrmel; Humlevik, Rasmus Olai Collett; Toska, Karen; Kalvenes, May Britt; Aas, Turid; Heie, Anette; Askeland, Cecilie; Knutsvik, Gøril; Stefansson, Ingunn Marie; Akslen, Lars Andreas; Høivik, Erling André; Wik, Elisabeth (Journal article; Peer reviewed, 2024)
      Breast cancer (BC) patients aged <40 years at diagnosis experience aggressive disease and poorer survival compared with women diagnosed with BC at 40 to 49 years, but the age-related biology is described to little extent. ...

    • Age-related phenotypes in breast cancer: A population-based study 

      Svanøe, Amalie Abrahamsen; Humlevik, Rasmus Olai Collett; Knutsvik, Gøril; Sæle, Anna Kristine Myrmel; Askeland, Cecilie; Ingebriktsen, Lise Martine; Hugaas, Ulrikke; Kvamme, Amalie Bark; Tegnander, Amalie Fagerli; Krüger, Kristi; Davidsen, Benedicte; Høivik, Erling André; Aas, Turid; Stefansson, Ingunn Marie; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2024)
      Breast cancer in young (<40 years) is associated with a higher frequency of aggressive tumor types and poor prognosis. It remains unclear if there is an underlying age-related biology that contributes to the unfavorable ...

    • Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer 

      Krüger, Kristi; Silwal-Pandit, Laxmi; Wik, Elisabeth; Straume, Oddbjørn; Stefansson, Ingunn Marie; Borgen, Elin; Garred, Øystein; Naume, Bjørn; Engebråten, Olav; Akslen, Lars Andreas (Journal article; Peer reviewed, 2021)
      A subset of breast cancer patients benefits from preoperative bevacizumab and chemotherapy, but validated predictive biomarkers are lacking. Here, we aimed to evaluate tissue-based angiogenesis markers for potential ...

    • CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis 

      Chen, Ying; Klingen, Tor Audun; Aas, Hans; Wik, Elisabeth; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)
      CD47 expressed on tumor cells binds to signal regulatory protein alpha on macrophages, initiating inhibition of phagocytosis. We investigated the relationships between tumor expression of CD47 and CD68 macrophage content, ...

    • Combining Mass Cytometry Data by CyTOFmerge Reveals Additional Cell Phenotypes in the Heterogeneous Ovarian Cancer Tumor Microenvironment: A Pilot Study 

      Thomsen, Liv Cecilie Vestrheim; Kleinmanns, Katrin; Anandan, Shamundeeswari; Gullaksen, Stein-Erik; Abdelaal, Tamim; Iversen, Grete Alræk; Akslen, Lars Andreas; Mc Cormack, Emmet; Bjørge, Line (Journal article; Peer reviewed, 2023-10-23)
      The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and ...

    • Detection and significance of small and low proliferation breast cancer 

      Hofvind, Solveig; Knutsvik, Gøril; Holen, Åsne Sørlien; Tsuruda, Kaitlyn; Akslen, Lars Andreas (Journal article; Peer reviewed, 2022)
      Objectives To determine the frequency and discuss possible implications of early breast cancer with particularly good prognosis and defined by tumor diameter and cell proliferation. Setting Detection of small and ...

    • Development of 42 marker panel for in-depth study of cancer associated fibroblast niches in breast cancer using imaging mass cytometry 

      Røgenes, Hanna; Finne, Kenneth; Winge, Ingeborg; Akslen, Lars Andreas; Östman, Arne; Milosevic, Vladan (Journal article; Peer reviewed, 2024)
      Imaging Mass Cytometry (IMC) is a novel, and formidable high multiplexing imaging method emerging as a promising tool for in-depth studying of tissue architecture and intercellular communications. Several studies have ...

    • Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010–2019 

      Thy, Jonas Evensen; Bhargava, Sameer; Larsen, Marthe; Akslen, Lars Andreas; Hofvind, Solveig Sand-Hanssen (Journal article; Peer reviewed, 2022)
      Aims: This study aimed to analyse results on early screening outcomes, including recall and cancer rates, and histopathological tumour characteristics among non-immigrants and immigrants invited to BreastScreen ...

    • Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features 

      Ingebriktsen, Lise Martine; Humlevik, Rasmus Olai Collett; Svanøe, Amalie Abrahamsen; Sæle, Anna Kristine Myrmel; Winge, Ingeborg; Toska, Karen; Kalvenes, May Britt; Davidsen, Benedicte; Heie, Anette; Knutsvik, Gøril; Askeland, Cecilie; Stefansson, Ingunn Marie; Høivik, Erling André; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2024)
      Background and objective Aurora kinase A (AURKA) is reported to be overexpressed in breast cancer. In addition to its role in regulating cell cycle and mitosis, studies have reported AURKA involvements in oncogenic ...

    • The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients 

      Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Mannelqvist, Monica; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2021)
      The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ...

    • Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer 

      Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars Andreas (Journal article; Peer reviewed, 2021)
      Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis ...

    • Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model 

      Bjørnstad, Ole Vidhammer; Carrasco Fernandez, Manuel; Finne, Kenneth; Ardawatia, Vandana; Winge, Ingeborg; Askeland, Cecilie; Arnes, Jarle; Knutsvik, Gøril; Kleftogiannis, Dimitrios; Paulo, Joao A.; Akslen, Lars Andreas; Vethe, Heidrun (Journal article; Peer reviewed, 2024)
      Background Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is emerging. A recent ...

    • Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus 

      Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria; Hoareau, Laurence; Røsland, Gro Vatne; Lu, Ning; Aanerud, Marianne; Gärtner, Fabian; Salminen, Pirjo-Riitta; Bentsen, Mariann; Halvorsen, Thomas; Ræder, Helge; Akslen, Lars Andreas; Langeland, Nina; Brokstad, Rebecca Jane Cox; Maury, Wendy; Stuhr, Linda Elin Birkhaug; Lorens, James; Engelsen, Agnete Svendsen Tenfjord (Journal article; Peer reviewed, 2022)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ...

    • Hypoxia induced responses are reflected in the stromal proteome of breast cancer 

      Kjølle, Silje; Finne, Kenneth; Birkeland, Even; Ardawatia, Vandana; Winge, Ingeborg; Aziz, Sura Mohammed; Knutsvik, Gøril; Wik, Elisabeth; Paulo, Joao A.; Vethe, Heidrun; Kleftogiannis, Dimitrios; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)
      Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) ...

    • Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1) 

      Ohnstad, Hege Oma; Blix, Egil Støre; Akslen, Lars Andreas; Gilje, Bjørnar; Raj, Sunil Xavier; Skjerven, Helle; Borgen, Elin; Janssen, Emiel; Mortensen, Elin Synnøve; Brekke, Marianne B.; Falk, Ragnhild Sørum; Schlichting, Ellen; Boge, Beate; Songe-Møller, Silje; Olsson, Pernilla Marie A.; Heie, Anette; Mannsåker, Bård; Vestlid, Magdalena Aas; Kursetgjerde, Torgunn; Gravdehaug, Berit; Suhrke, Pål; Sánchez, E.; Bublevic, J.; Røe, Oluf Dimitri; Geitvik, Gry; Halset, Eline Holli; Rypdal, Maria Christine; Langerød, Anita; Lømo, Jon; Garred, Øystein; Porojnicu, Alina Carmen; Engebraaten, O.; Geisler, Jürgen; Lyngra, Marianne; Hansen, M. H.; Søiland, Håvard; Nakken, T.; Asphaug, Lars; Kristensen, Vessela N.; Sørlie, Therese; Sørlie, T.; Nygård, Jan Franz; Kiserud, Cecilie E.; Reinertsen, Kristin Valborg; Russnes, Hege Elisabeth Giercksky; Naume, Bjørn (Journal article; Peer reviewed, 2024)
      Background EMIT-1 is a national, observational, single-arm trial designed to assess the value of the Prosigna, Prediction Analysis of Microarray using the 50 gene classifier (PAM50)/Risk of Recurrence (ROR), test as a ...

    • Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models 

      Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James; Dyrstad, Sissel Elisabeth; Ekanger, Camilla Tvedt; Lu, Ning; Frantz, Kirstine; Stuhr, Linda Elin Birkhaug; Ditzel, Henrik J.; Thiery, Jean Paul; Akslen, Lars Andreas; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2022)
      The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional ...

    • LOCATOR: feature extraction and spatial analysis of the cancer tissue microenvironment using mass cytometry imaging technologies 

      Ehsani, Rezvan; Jonassen, Inge; Akslen, Lars Andreas; Kleftogiannis, Dimitrios (Journal article; Peer reviewed, 2023)
      Motivation Recent advances in highly multiplexed imaging have provided unprecedented insights into the complex cellular organization of tissues, with many applications in translational medicine. However, downstream ...

    • Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer 

      Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)
      Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ...

    • A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer 

      Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2022)
      Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ...

    • A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer 

      Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)
      Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ...