Browsing Bergen Open Research Archive by Author "Alam, Jahedul"
Now showing items 1-5 of 5
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Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
Zeltz, Cedric; Primac, Irina; Murugan Erusappan, Pugazendhi; Alam, Jahedul; Noel, Agnes; Gullberg, Donald (Peer reviewed; Journal article, 2019)The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ... -
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Alam, Jahedul; Musiime, Moses; Romaine, Andreas; Sawant, Mugdha; Melleby, Arne Olav; Lu, Ning; Eckes, Beate; Christensen, Geir; Gullberg, Donald (Journal article; Peer reviewed, 2020)Cell-specific expression of genes offers the possibility to use their promoters to drive expression of Cre-recombinase, thereby allowing for detailed expression analysis using reporter gene systems, cell lineage tracing, ... -
Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation
Murugan Erusappan, Pugazendhi; Alam, Jahedul; Lu, Ning; Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2019)Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ... -
Novel Insights into Integrin α11 Expression and Function
Alam, Jahedul (Doctoral thesis, 2020-01-31)Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ... -
α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration
Zeltz, Cedric; Alam, Jahedul; Liu, Hengshuo; Erusappan, Pugazendhi M; Hoschuetzky, Heinz; Molven, Anders; Parajuli, Himalaya; Cukierman, Edna; Costea, Daniela Elena; Lu, Ning; Gullberg, Donald (Peer reviewed; Journal article, 2019-06-01)Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further ...