Blar i Bergen Open Research Archive på forfatter "Alnæs, Dag"
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Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; Alnæs, Dag; Kaufmann, Tobias; Westlye, Lars Tjelta; Steen, Vidar Martin; Andreassen, Ole Andreas; Hughes, Timothy; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)Background Altered expression of the complement component C4A gene is a known risk factor for schizophrenia. Further, predicted brain C4A expression has also been associated with memory function highlighting that altered ... -
Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology
van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article; Peer reviewed, 2022)Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ... -
Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study
Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ... -
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik G.; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2018-10-02)The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ... -
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2019)Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ... -
Diffusion Tensor Imaging Before and 3 Months After Concentrated Exposure Response Prevention in Obsessive-Compulsive Disorder
Brecke, Vilde; Thorsen, Anders Lillevik; Ousdal, Olga Therese; Vriend, Chris; Alnæs, Dag; Hagen, Kristen; Hansen, Bjarne; Kvale, Gerd; van den Heuvel, Odile A (Journal article; Peer reviewed, 2021)Background: Subtle differences in white matter microstructure have been found in obsessive-compulsive disorder (OCD) compared to controls using diffusion tensor imaging (DTI), but it is unclear if and how this change after ... -
Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders
Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik G.; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O’ Connell, Kevin S.; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar M.; Tsolaki, Magda; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Kaufmann, Tobias (Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of the human cerebral cortex
Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Agartz, Ingrid; Alnæs, Dag; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Sønderby, Ida Elken; van der Meer, Dennis; Westlye, Lars Tjelta; Wolfers, Thomas; Djurovic, Srdjan; Le Hellard, Stephanie; Andreassen, Ole Andreas; Jönsson, Erik Gunnar; Steen, Vidar Martin; Medland, Sarah E. (Journal article; Peer reviewed, 2020)INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be ... -
Genetic control of variability in subcortical and intracranial volumes
Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E. (Journal article; Peer reviewed, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank
Bøen, Rune; Kaufmann, Tobias; Frei, Oleksandr; van der Meer, Dennis; Djurovic, Srdjan; Andreassen, Ole; Selmer, Kaja Kristine; Alnæs, Dag; Sønderby, Ida Elken (Journal article; Peer reviewed, 2023)The 15q11.2 BP1-BP2 copy number variant (CNV) is associated with altered brain morphology and risk for atypical development, including increased risk for schizophrenia and learning difficulties for the deletion. However, ... -
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood
Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...