Browsing Bergen Open Research Archive by Author "Andreassen, Ole A."

Now showing items 1-18 of 18

    • Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study 

      Askelund, Adrian Dahl; Wootton, Robyn E.; Torvik, Fartein A.; Lawn, Rebecca B.; Ask, Helga; Corfield, Elizabeth C.; Magnus, Maria C.; Reichborn-Kjennerud, Ted; Magnus, Per M.; Andreassen, Ole A.; Stoltenberg, Camilla; Davey Smith, George; Davies, Neil Martin; Havdahl, Alexandra; Hannigan, Laurie John (Journal article; Peer reviewed, 2024)
      Background The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates of depression in adolescents. Previous research ...

    • Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa) 

      Wootton, Robyn E.; Lawn, Rebecca B.; Magnus, Maria C.; Treur, Jorien L.; Corfield, Elizabeth C.; Njølstad, Pål Rasmus; Andreassen, Ole A.; Lawlor, Deborah A.; Munafò, Marcus R.; Håberg, Siri E.; Smith, George Davey; Reichborn-Kjennerud, Ted; Magnus, Per; Havdahl, Alexandra (Journal article; Peer reviewed, 2023)
      Background Guidance to improve fertility includes reducing alcohol and caffeine consumption, achieving healthy weight-range and stopping smoking. Advice is informed by observational evidence, which is often biased by ...

    • Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health 

      Johannessen, Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Kaale, Anett; Wirgenes, Katrine V.; Malt, Eva; Djurovic, Srdjan; Rietschel, Marcella; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Clinical relevance of genetic testing is increasing in autism spectrum disorder (ASD). Information about genetic risk may contribute to improved diagnostics, treatment and family planning, but may also be perceived as a ...

    • Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder 

      Diemer, Elizabeth W.; Havdahl, Alexandra; Andreassen, Ole A.; Munafò, Marcus R.; Njølstad, Pål Rasmus; Tiemeier, Henning; Zuccolo, Luisa; Swanson, Sonja A. (Journal article; Peer reviewed, 2023)
      Background As large-scale observational data become more available, caution regarding causal assumptions remains critically important. This may be especially true for Mendelian randomisation (MR), an increasingly popular ...

    • Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders 

      Gjerde, Kristian Varden; Bartz-Johannessen, Christoffer; Steen, Vidar Martin; Andreassen, Ole A.; Steen, Nils Eiel; Ueland, Thor; Lekva, Tove; Rettenbacher, Maria; Joa, Inge; Reitan, Solveig Klæbo; Johnsen, Erik; Kroken, Rune Andreas (Journal article; Peer reviewed, 2024)
      Background Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells ...

    • Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes 

      O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Cheng, Weiqiu; Chu, Yunhan; Hindley, Guy; Lin, Aihua; Shadrin, Alexey; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Steen, Nils Eiel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Background: A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ...

    • Divergent epigenetic responses to perinatal asphyxia in severe mental disorders 

      Bakke, Laura Anne Wortinger; Stavrum, Anne-Kristin Støbakk; Shadrin, Alexey; Szabo, Attila; Rukke, Sondre Høeg; Nerland, Stener; Smelror, Runar Elle; Jørgensen, Kjetil Nordbø; Barth, Claudia; Andreou, Dimitrios; Weibell, Melissa Anne Elin Authen; Djurovic, Srdjan; Andreassen, Ole A.; Thoresen, Marianne; Ursini, Gianluca; Agartz, Ingrid; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2024)
      Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these ...

    • Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood? 

      Jami, Eshim S.; Hammerschlag, Anke R.; Sallis, Hannah M.; Qiao, Zhen; Andreassen, Ole A.; Magnus, Per Minor; Njølstad, Pål Rasmus; Havdahl, Alexandra; Pingault, Jean-Baptiste; Evans, David M.; Munafò, Marcus R.; Ystrom, Eivind; Bartels, Meike; Middeldorp, Christel (Journal article; Peer reviewed, 2023)
      Parental genes may indirectly influence offspring psychiatric outcomes through the environment that parents create for their children. These indirect genetic effects, also known as genetic nurture, could explain individual ...

    • Early manifestations of genetic risk for neurodevelopmental disorders 

      Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole A.; Smith, George Davey; Reichborn-Kjennerud, Ted; Havdahl, Alexandra (Journal article; Peer reviewed, 2021)
      Background: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important ...

    • Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder 

      Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan; Matziorinis, Anna Maria; Beck, Dani; Richard, Geneviève; Sæther, Linn Sofie; Haatveit, Beathe; Nordvik, Jan Egil; Hatlestad-Hall, Christoffer; Einevoll, Gaute T.; Mäki-Marttunen, Tuomo; Haram, Marit; Ueland, Torill; Lagerberg, Trine V.; Steen, Nils Eiel; Melle, Ingrid; Westlye, Lars T.; Jönsson, Erik Gunnar; Andreassen, Ole A.; Moberget, Torgeir; Elvsåshagen, Torbjørn (Journal article; Peer reviewed, 2021)
      Several lines of research suggest that impairments in long-term potentiation (LTP)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (SZ) and bipolar disorder type I (BDI) and II (BDII). ...

    • Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci 

      Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Lin, Aihua; Cheng, Weiqiu; Steen, Nils Eiel; Shadrin, Alexey; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole A.; Smeland, Olav Bjerkehagen (Journal article; Peer reviewed, 2022)
      Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness ...

    • GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis 

      Skuladottir, Astros Th; Stefansdottir, Lilja; Halldorsson, Gisli H.; Stefansson, Olafur A.; Bjornsdottir, Anna; Jonsson, Palmi; Palmadottir, Vala; Thorgeirsson, Thorgeir E.; Walters, G Bragi; Gisladottir, Rosa S.; Bjornsdottir, Gyda; Jonsdottir, Gudrun A.; Sulem, Patrick; Gudbjartsson, Daniel F.; Knowlton, Kirk U.; Jones, David A.; Ottas, Aigar; Pedersen, Ole B.; Didriksen, Maria; Brunak, Søren; Banasik, Karina; Hansen, Thomas Folkmann; Erikstrup, Christian; Haavik, Jan; Andreassen, Ole A.; Rye, David; Igland, Jannicke; Ostrowski, Sisse Rye; Milani, Lili A.; Nadauld, Lincoln D.; Stefansson, Hreinn; Stefansson, Kari (Journal article; Peer reviewed, 2024)
      Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets, ...

    • How real-world data can facilitate the development of precision medicine treatment in psychiatry 

      Koch, Elise Mirjam; Pardiñas, Antonio F.; O'Connell, Kevin Sean; Selvaggi, Pierluigi; Camacho-Collados, Jose; Babic, Aleksandar; Marshall, Serena Elizabeth; Van der Eycken, Erik; Angulo, Cecilia; Lu, Yi; Sullivan, Patrick F.; Dale, Anders M; Molden, Espen; Posthuma, Danielle; White, Nathan; Schubert, Alexander; Djurovic, Srdjan; Heimer, Hakon; Stefánsson, Hreinn; Stefánsson, Kári; Werge, Thomas; Sønderby, Ida Elken; O’Donovan, Michael C.; Walters, James T.R.; Milani, Lili; Andreassen, Ole A. (Journal article; Peer reviewed, 2024)
      Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification and holds great potential for the treatment of mental disorders. However, several important factors are ...

    • Identification of pleiotropy at the gene level between psychiatric disorders and related traits 

      Polushina, Tatiana; Banerjee, Niladri; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri J.; Djurovic, Srdjan; Cichon, Sven; Hoffmann, Per; Nöthen, Markus M.; Steen, Vidar Martin; Andreassen, Ole A.; Le Hellard, Stéphanie (Journal article; Peer reviewed, 2021)
      Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ...

    • Modeling assortative mating and genetic similarities between partners, siblings, and in-laws 

      Torvik, Fartein Ask; Eilertsen, Espen Moen; Hannigan, Laurie J.; Cheesman, Rosa; Howe, Laurence J.; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Andreassen, Ole A.; Njølstad, Pål Rasmus; Havdahl, Alexandra; Ystrøm, Eivind (Journal article; Peer reviewed, 2022)
      Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners ...

    • Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia 

      Tesfaye, Markos; Spindola, Leticia Maria Nery; Stavrum, Anne-Kristin Støbakk; Shadrin, Alexey; Melle, Ingrid; Andreassen, Ole A.; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2024)
      Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of ...

    • Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients 

      Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine V.; Steen, Nils Eiel; Andreassen, Ole A.; Steen, Vidar M.; Melle, Ingrid (Journal article; Peer reviewed, 2021)
      Background: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic ...

    • Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 

      Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide ...