Browsing Bergen Open Research Archive by Author "Andresen, Vibeke"
Now showing items 1-6 of 6
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Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel; Sulen, Andre; Popa, Mihaela Lucia; Sørnes, Steinar; Reikvam, Håkon; Chan, Kok-Ping; Hovland, Randi; McCormack, Emmet; Bruserud, Øystein; Myers, Andrew G.; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-12-01)Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ... -
Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia
Leitch, Calum; Osdal, Tereza; Andresen, Vibeke; Molland, Maren Kristine Butler; Kristiansen, Silje Elisabeth; Nguyen, Nhi Xuan; Bruserud, Øystein; Gjertsen, Bjørn Tore; McCormack, Emmet (Peer reviewed; Journal article, 2016)Palliative care in acute myeloid leukaemia (AML) is inadequate. For elderly patients, unfit for intensive chemotherapy, median survival is 2–3 months. As such, there is urgent demand for low-toxic palliative alternatives. ... -
Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms
Rende, Francesca; Cavallari, Ilaria; Andresen, Vibeke; Valeri, Valerio W.; D'Agostino, Donna M.; Franchini, Genoveffa; Ciminale, Vincenzo (Peer reviewed; Journal article, 2015-07-02)Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression ... -
Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine
Omsland, Maria; Pise-Masison, Cynthia A.; Fujikawa, Dai; Galli, Veronica; Fenizia, Claudio; Parks, Robyn Washington; Gjertsen, Bjørn Tore; Franchini, Genoveffa; Andresen, Vibeke (Peer reviewed; Journal article, 2018-07-24)The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, bioflm-like structures ... -
The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1
Tosi, Giovanna; Forlani, Greta; Andresen, Vibeke; Turci, Marco; Bertazzoni, Umberto; Franchini, Genoveffa; Accolla, Roberto S. (Conference object; Peer reviewed, 2011-06-06) -
Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines (
Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik; Ayuda-Duran, Maria del Pilar; Popa, Mihaela Lucia; Hovland, Randi; Brendehaug, Atle; Enserink, Jorrit; Mc Cormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are proposed to be important for optimal therapy response. Tunneling ...