Browsing Bergen Open Research Archive by Author "Arnesen, Victoria Smith"
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Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy
Arnesen, Victoria Smith; Gras Navarro, Andrea; Enger, Martha (Journal article; Peer reviewed, 2021)Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment ... -
Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ... -
Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins
Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; D'Santos, Clive S.; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ... -
Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
Mazloumi Gavgani, Fatemeh; Karlsson, Thomas; Tangen, Ingvild Løberg; Papdine Morovicz, Andrea; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; Spang, Katharina Maria; Krakstad, Camilla; Guillermet-Guibert, Julie; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ... -
Role of the class I PI3K p110ß and PtdIns(3,4,5)P3 in rRNA transcription in the nucleolus
Arnesen, Victoria Smith (Master thesis, 2018-06-26)The phosphoinositide 3-kinase (PI3K) signalling pathway is one of the most altered pathways in human cancer. It is a complex pathway, when considering that ubiquitously expressed isoforms regulate different routes with ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ...