• Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 

      Bruno, Raphael Romano; Wernly, Bernhard; Wolff, Georg; Fjølner, Jesper; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C.; Kindgen-Milles, Detlef; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Topeli, Arzu; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Jung, Christian (Journal article; Peer reviewed, 2022)
      Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes ...
    • Cumulative prognostic score predicting mortality in patients older than 80 years admitted to the ICU 

      de Lange, Dylan W.; Brinkman, Sylvia; Flaatten, Hans; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Bollen Pinto, Bernardo; de Smet, Anne Marie G.A.; Soliman, Ivo W.; Szczeklik, Wojciech; Valentin, Andreas; Watson, Ximena; Zafeiridis, Tilemachos; Guidet, Bertrand (Peer reviewed; Journal article, 2019-06)
      OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of ...
    • Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

      Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...
    • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

      Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Journal article; Peer reviewed, 2022)
      Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...
    • Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years 

      Soliman, Ivo W; Leaver, Susannah; Flaatten, Hans Kristian; Fjølner, Jesper; Wernly, Bernhard; Bruno, Raphael R; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C; Beil, Michael; Sviri, Sigal; Van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Wollborn, Jakob; Banzo, Maria Jose Arche; Fuest, Kristina; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Boumendil, Ariane; Guidet, Bertrand; Jung, Christian; De Lange, Dylan W (Journal article; Peer reviewed, 2022)
      Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to ...
    • Huge variation in obtaining ethical permission for a non-interventional observational study in Europe 

      de Lange, Dylan W.; Guidet, Bertrand R.; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Moreno, Rui; Christensen, Steffen; Cecconi, Maurizio; Agvald-Öhman, Christina; Gradišek, Primož; Jung, Christian; Marsh, Brian J.; Oeyen, Sandra; Bollen Pinto, Bernardo; Szczeklik, Wojciech; Watson, Ximena; Zafeiridis, Tilemachos; Flaatten, Hans (Peer reviewed; Journal article, 2019-06-03)
      Background Ethical approval (EA) must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Methods Sixteen European national ...
    • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study 

      Jung, Christian; Flaatten, Hans; Fjølner, Jesper; Romano Bruno, Raphael; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand (Journal article; Peer reviewed, 2021)
      Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in ...
    • Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients 

      Bruno, Raphael Romano; Wernley, Bernhard; Flaatten, Hans; Fjølner, Jesper; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Binnebössel, Stephan; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sigal, Sivri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Wollborn, Jakob; Banzo, Maria José Arche; Fuest, Kristina; Marsh, Brian; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2021)
      Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ...
    • Management and outcomes in critically ill nonagenarian versus octogenarian patients 

      Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2021)
      Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...
    • Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study 

      Polok, Kamil; Fronczek, Jakub; Artigas, Antonio; Flaatten, Hans Kristian; Guidet, Bertrand; De Lange, Dylan W.; Fjølner, Jesper; Leaver, Susannah; Beil, Michael; Sviri, Sigal; Bruno, Raphael Romano; Wernly, Bernhard; Bollen Pinto, Bernardo; Schefold, Joerg C.; Studzińska, Dorota; Joannidis, Michael; Oeyen, Sandra; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Jung, Christian; Szczeklik, Wojciech (Journal article; Peer reviewed, 2022)
      Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. ...
    • Relationship between the Clinical Frailty Scale and short‑term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. 

      Fronczek, Jakub; Polok, Kamil; de Lange, Dylan W.; Jung, Christian; Beil, Michael; Rhodes, Andrew; Fjølner, Jesper; Górka, Jacek; Andersen, Finn H.; Artigas, Antonio; Cecconi, Maurizio; Christensen, Steffen; Flaatten, Hans; Szczeklik, Wojciech (Journal article; Peer reviewed, 2021)
      Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...
    • Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study 

      Flaatten, Hans; Guidet, Bertrand; Andersen, Finn Husøy; Artigas, Antonio; Cecconi, Maurizio; Boumendil, Ariane; Elhadi, Muhammed; Fjølner, Jesper; Joannidis, Michael; Jung, Christian; Leaver, Susannah; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Nalapko, Yuriy; Schefold, Joerg C.; Szczeklik, Wojciech; Walther, Sten; Watson, Ximena; Zafeiridis, Tilemachos; de Lange, Dylan W. (Journal article; Peer reviewed, 2021)
      Purpose Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed ...
    • A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems 

      Wernly, Bernhard; Flaatten, Hans Kristian; Beil, Michael; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Kelm, Malte; Sigal, Sviri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Rezar, Richard; Oeyen, Sandra; Wolff, Georg; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Wernly, Sarah; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Perings, Stefan; Jung, Christian (Journal article; Peer reviewed, 2022)
      In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in ...
    • Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study 

      Ibarz, Mercedes; Boumendil, Ariane; Flaatten, Hans; Andersen, Finn Husøy; Artigas, Antonio; Haas, Lenneke E. M.; Irazabal, Marian; de Lange, Dylan W.; Morandi, Alessandro; Bertolini, Guido; Cecconi, Maurizio; Christensen, Stefen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernardo Bollen; Soliman, Ivo W.; Valentin, Andreas; Szczeklik, Wojciech; Watson, Ximena; Zaferidis, Tilemachos; Guidet, Bertrand; Artigas, Antonio (Journal article; Peer reviewed, 2020)
      Background The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. ...
    • Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

      Wernly, Bernhard; Bruno, Raphael Romano; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Muessig, Johanna M.; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernadro Bollen; Soliman, Ivo W.; Szczeklik, Wojciech; Niederseer, David; Valentin, Andreas; Watson, Ximena; Leaver, Susannah; Boulanger, Carole; Walther, Sten; Schefold, Jörg C.; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Zafeiridis, Tilemachos; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2020)
      Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...
    • Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study 

      Wolff, Georg; Wernly, Bernhard; Flaatten, Hans Kristian; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Kelm, Malte; Binneboessel, Stephan; Baldia, Philipp; Beil, Michael; Sivri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Flamm, Maria; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Leaver, Susannah; Jung, Christian (Journal article; Peer reviewed, 2022)
      Purpose Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific ...
    • Steroid use in elderly critically ill COVID-19 patients 

      Jung, Christian; Wernly, Bernhard; Fjølner, Jesper; Bruno, Raphael Romano; Dudzinski, David; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Jörg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sigal, Sviri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Mirosław; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2021)
      This secondary analysis of the COVIP study shows a higher 30-day mortality in critically ill elderly COVID-19 patients who received steroids as part of their treatment