Browsing Bergen Open Research Archive by Author "Ashrafi, Hanan"

Now showing items 1-3 of 3

    • The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress 

      Ashrafi, Hanan (Master thesis, 2019-06-28)
      Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ...

    • Structure to function analysis with antigenic characterization of a hypothetical protein, HPAG1_0576 from Helicobacter pylori HPAG1 

      Ashrafi, Hanan; Siraji, Muntequa Ishtiaq; Showva, Nazmir Nur; Hossain, Md. Mozamme; Hossan, Tareq; Hasan, Md. Ashraful; Shohael, Abdullah Mohammad; Shawan, Mohammad Mahfuz Ali Khan (Peer reviewed; Journal article, 2019-07-31)
      Helicobacter pylori, a unique gastric pathogen causing chronic inflammation in the gastric mucosa with a possibility to develop gastric cancer has one-third of its proteins still uncharacterized. In this study, a hypothetical ...

    • Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation 

      Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena; Liu, Xiao-Zheng; Hodneland, Linn I.; Løvsletten, Nils Gunnar; Berge, Kjetil; Wergedahl, Hege; Bjørndal, Bodil; Fluge, Øystein; Bruland, Ove; Rustan, Arild; Halberg, Nils; Røsland, Gro Vatne; Berge, Rolf Kristian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2019)
      Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ...