• Cardiac organ damage in systemic hypertension: Impact of gender, etiology, and comorbidities 

      Aune, Arleen (Doctoral thesis, 2024-03-15)
      Bakgrunn: Ukontrollert systemisk hypertensjon fører til økt risiko for kardiovaskulær sykdom og død både ved essensiell og sekundær hypertensjon. Den økte risikoen skyldes i stor grad utvikling av strukturelle og funksjonelle ...
    • Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations 

      Bergland, Ola Undrum; Halvorsen, Lene Vernås; Søraas, Camilla Lund; Hjørnholm, Ulla; Kjær, Vibeke Norheim; Rognstad, Stine; Brobak, Karl Marius; Aune, Arleen; Olsen, Eirik; Fauchald, Ylva; Heimark, Sondre; Thorstensen, Christian W; Liestøl, Knut; Solbu, Marit Dahl; Gerdts, Eva; Mo, Rune; Rostrup, Morten; Kjeldsen, Sverre; Høieggen, Aud; Opdal, Mimi Stokke; Fadl Elmula, Fadl Elmula M. (Journal article; Peer reviewed, 2021)
      Nonadherence to drugs is a challenge in hypertension treatment. We aimed to assess the prevalence of nonadherence by serum drug concentrations compared with 2 indirect methods and relate to the prescribed drug regimens in ...
    • Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension 

      Thorstensen, Christian W.; Clasen, Per-Erik; Rognstad, Stine; Haldsrud, Renate; Føreid, Siri; Helstrøm, Trine; Bergland, Ola Undrum; Halvorsen, Lene Vernås; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Høieggen, Aud; Gustavsen, Ingebjørg G.; Larstorp, Anne Cecilie Kjeldsen; Søraas, Camilla Lund; Opdal, Mimi Stokke (Journal article; Peer reviewed, 2022)
      We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLC-MS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, ...
    • Effect of Therapeutic Drug Monitoring on Adherence and Blood Pressure: A Multicenter Randomized Clinical Trial 

      Halvorsen, Lene Vernås; Søraas, Camilla Lund; Larstorp, Anne Cecilie Kjeldsen; Hjørnholm, Ulla; Kjær, Vibeke Norheim; Liestøl, Knut; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Bergland, Ola Undrum; Rognstad, Stine; Aarskog, Nikolai Ravn; Heimark, Sondre; Fadl Elmula, Fadl Elmula M.; Gerdts, Eva; Mo, Rune; Solbu, Marit Dahl; Opdal, Mimi Stokke; Kjeldsen, Sverre; Rostrup, Morten; Høieggen, Aud (Journal article; Peer reviewed, 2024)
      Background: Drug concentration in blood or urine is an acknowledged method to detect nonadherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). ...
    • Gender Differences in Cardiac Organ Damage in Arterial Hypertension: Assessing the Role of Drug Nonadherence 

      Aune, Arleen; Ohldieck, Annabel Eide; Halvorsen, Lene Vernås; Brobak, Karl Marius; Olsen, Erik; Rognstad, Stine; Larstorp, Anne Cecilie Kjeldsen; Søraas, Camilla Lund; Rossebø, Anne Bjørhovde; Rösner, Assami; Grytaas, Marianne Aardal; Gerdts, Eva (Journal article; Peer reviewed, 2024)
      Introduction Cardiac organ damage like left ventricular (LV) hypertrophy and left atrial (LA) enlargement is more prevalent in women than men with hypertension, but the mechanisms underlying this gender difference remain ...
    • Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage 

      Brobak, Karl Marius; Halvorsen, Lene Vernås; Aass, Hans Christian; Søraas, Camilla Lund; Aune, Arleen; Olsen, Erik; Bergland, Ola Undrum; Rognstad, Stine; Blom, Kjersti Benedicte; Birkeland, Jon Arne; Høieggen, Aud; Larstorp, Anne Cecilie Kjeldsen; Solbu, Marit Dahl (Journal article; Peer reviewed, 2024)
      Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional ...
    • Persistent cardiac organ damage in surgically and medically treated primary aldosteronism 

      Aune, Arleen; Gerdts, Eva; Kokorina, Marina Victorovna; Kringeland, Ester Anne; Midtbø, Helga Bergljot; Løvås, Kristian; Grytaas, Marianne (Journal article; Peer reviewed, 2022)
      Objective: We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism. Methods: Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism ...
    • Preclinical cardiac disease in women and men with primary aldosteronism 

      Aune, Arleen; Kokorina, Marina Victorovna; Grytaas, Marianne Aa.; Midtbø, Helga Bergljot; Løvås, Kristian; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking ...