Browsing Bergen Open Research Archive by Author "Azeem, Waqas"

Now showing items 1-6 of 6

    • Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes 

      Olsen, Jan R; Azeem, Waqas; Hellem, Margrete R; Marvyin, Kristo; Hua, Yaping; Qu, Yi; Li, Lisha; Lin, Biaoyang; Ke, XI- S; Øyan, Anne Margrete; Kalland, Karl-Henning (Peer reviewed; Journal article, 2016-07-04)
      Background Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required ...

    • Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells 

      Azeem, Waqas; Bakke, Ragnhild Maukon; Gabriel, Benjamin; Appel, Silke; Øyan, Anne Margrete; Kalland, Karl-Henning (Journal article; Peer reviewed, 2021)
      Modulation of β-catenin signaling has attractive therapeutic potential in cancer immunotherapy. Several studies have found that β-catenin can mediate immune evasion in cancer and promote anti-inflammatory features of ...

    • GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 

      Lellahi, Seyed Mohammad; Azeem, Waqas; Hua, Yaping; Gabriel, Benjamin; Rye, Kristin Paulsen; Reikvam, Håkon; Kalland, Karl Henning (Journal article; Peer reviewed, 2023-01-12)
      Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. Use of cDCs ...

    • Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain 

      Hua, Yaping; Yuan, Xing; Shen, Yun-Heng; Wang, Jinxin; Azeem, Waqas; Yang, Shuo; Gade, Alexandra; Lellahi, Seyed Mohammad; Øyan, Anne Margrete; Ke, Xisong; Zhang, Wei-Dong; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ...

    • A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer 

      Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)
      Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ...

    • Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells 

      Azeem, Waqas; Olsen, Jan Roger; Hellem, Margrete Reime; Hua, Yaping; Marvyin, Kristo; Ke, Xisong; Øyan, Anne Margrete; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ...