• AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction 

      Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)
      The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ...
    • Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model 

      Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)
      Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ...
    • The Effect of Melatonin on Periodontitis 

      Konečná, Barbora; Chobodová, Paulína; Janko, Jakub; Baňasová, Lenka; Babickova, Janka; Celec, Peter; Tóthová, L’Ubomíra (Journal article; Peer reviewed, 2021)
      Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute ...
    • Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission 

      Vrablicova, Zuzana; Tomova, Kristina; Tothova, Lubomira; Babickova, Janka; Gromova, Barbora; Konecna, Barbora; Liptak, Robert; Hlavaty, Tibor; Gardlik, Roman (Journal article; Peer reviewed, 2020)
      Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ...
    • Oxidative Stress in Animal Models of Acute and Chronic Renal Failure 

      Gyuraszova, Marianna; Kovalcikova, Alexandra Gaal; Renczes, Emese; Kmetova, Katarina; Celec, Peter; Babickova, Janka; Tothova, Lubomira (Peer reviewed; Journal article, 2019-02-11)
      Introduction. Kidney disease is a worldwide health and economic burden, with rising prevalence. The search for biomarkers for earlier and more effective disease screening and monitoring is needed. Oxidative stress has been ...
    • Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers 

      Gyurászová, Marianna; Gurecká, Radana; Babickova, Janka; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2020)
      Kidney disease represents a serious global health problem. One of the main concerns is its late diagnosis, only feasible in a progressed disease state. The lack of a clinical manifestation in the early stages and the fact ...
    • Plasma Concentrations of Extracellular DNA in Acute Kidney Injury 

      Homolová, Jordanka; Janovičová, L'ubica; Konečná, Barbora; Vlková, Barbora; Celec, Peter; Tóthová, L'ubomíra; Babickova, Janka (Journal article; Peer reviewed, 2020)
      Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover ...