Browsing Bergen Open Research Archive by Author "Bariås, Espen"
Now showing items 1-3 of 3
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Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization
Jakubec, Martin; Bariås, Espen; Furse, Samuel Robert; Govasli Larsen, Morten Andreas; George, Vinnit; Turcu, Diana Cornelia; Iashchishyn, Igor A.; Morozova-Roche, Ludmilla A.; Halskau, Øyvind (Journal article; Peer reviewed, 2021)Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in many neurological diseases, including Parkinson's disease. Misfolding of α-synuclein (α-Syn), the main actor in Parkinson's disease, ... -
Contrasting the phospholipid profiles of two neoplastic cell lines reveal a high PC:PE ratio for SH-SY5Y cells relative to A431 cells
Bariås, Espen; Jakubec, Martin; Førsund, Elise; Hjørnevik, Linda Veka; Lewis, Aurelia Eva; Halskau, Øyvind (Journal article; Peer reviewed, 2023)Lipids have been implicated in Parkinson's Disease (PD). We therefore studied the lipid profile of the neuroblastoma SH-SY5Y cell line, which is used extensively in PD research and compared it to that of the A431 epithelial ... -
Fast and Quantitative Phospholipidomic Analysis of SH-SY5Y Neuroblastoma Cell Cultures Using LC-MS/MS and 31P NMR
Jakubec, Martin; Bariås, Espen; Kryuchkov, Fedor; Hjørnevik, Linda Veka; Halskau, Øyvind (Peer reviewed; Journal article, 2019)Global lipid analysis still lags behind proteomics with respect to the availability of databases, experimental protocols, and specialized software. Determining the lipidome of cellular model systems in common use is of ...