Browsing Bergen Open Research Archive by Author "Beisland, Christian"
Now showing items 1-17 of 17
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The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
Aarstad, Helene Hersvik; Gudbrandsdottir, Gigja; Hjelle, Karin; Bostad, Leif; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ... -
Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis
Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ... -
Elevated plasma interleukin 6 predicts poor response in patients treated with sunitinib for metastatic clear cell renal cell carcinoma
Pilskog, Martin; Nilsen, Gry Hilde; Beisland, Christian; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)Introduction: Clear cell renal cell carcinoma (ccRCC) is the most common type among renal cell carcinomas, and anti-angiogenic treatment is currently first line therapy in metastatic ccRCC (mccRCC). Response rates and ... -
Epidemiological and clinical aspects in diagnosis and treatment of renal cell carcinoma
Beisland, Christian (Doctoral thesis, 2006-02-24) -
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Mannelqvist, Monica; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
Eikrem, Øystein Solberg; Walther, Tedd Christian; Flatberg, Arnar; Beisvag, Vidar; Strauss, Philipp; Farstad, Magnus; Beisland, Christian; Koch, Even; Mueller, Thomas F.; Marti, Hans-Peter (Peer reviewed; Journal article, 2018-09-18)Background: Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer
Børretzen, Astrid; Gravdal, Karsten; Haukaas, Svein Andreas; Beisland, Christian; Akslen, Lars A.; Halvorsen, Ole Johan (Peer reviewed; Journal article, 2019)Epithelial–mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression ... -
Higher than expected and significantly increasing incidence of upper tract urothelial carcinoma. A population based study
Almås, Bjarte; Halvorsen, Ole Johan; Johannessen, Tom Børge; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose: To register all cases of urothelial cancer and renal cell carcinoma (RCC) in Norway during 1999–2018 to obtain the contemporary incidence of UTUC and UTUC incidence relative to other urothelial cancers and RCC. ... -
The levels of IL-6 and soluble IL-33R are increased in the renal vein during surgery for clear cell renal cell carcinoma
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Hjelle, Karin Margrethe; Førde, Kristina; Reisæter, Lars Anders Rokne; Bostad, Leif; Aarstad, Hans Jørgen; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose The main aim was to map serum levels of IL-1/IL-6 family cytokines and relevant receptors from serum samples taken across treatment in patients with Renal Cell Carcinoma (RCC). Additionally, we explored the possible ... -
Multiple primary malignancies in patients with Renal Cell Carcinoma. - A national population-based cohort study
Beisland, Christian; Talleraas, Olaug; Bakke, August; Norstein, Jarle (BJU Int, to be published, Journal article, 2006) -
National Norwegian Practice Patterns for Surgical Treatment of Kidney Cancer Tumors ≤7 cm: Adherence to Changes in Guidelines May Improve Overall Survival
Hjelle, Karin Margrethe; Johannesen, Tom B.; Bostad, Leif; Reisæter, Lars A. R.; Beisland, Christian (Peer reviewed; Journal article, 2018-08)Background: Guidelines on surgical treatment for kidney cancer (KC) have changed over the last 10 yr. We present population-based data for patients with KC tumors ≤7 cm from 2008 to 2013 to investigate whether surgical ... -
Non-metastatic prostate cancer: rationale for conservative treatment and impact on disease-related morbidity and mortality in the elderly
Löffeler, Sven; Halland, Adrian; Fawad, Haris; Beisland, Christian; Haug, Erik Skaaheim (Journal article; Peer reviewed, 2020)Purpose: To determine the rationale for not offering local treatment to prostate cancer patients with non-metastatic disease at diagnosis who later died of prostate cancer and to document local and systemic complications ... -
A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy
Nygård, Yngve; Haukaas, Svein A.; Halvorsen, Ole J.; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian (Peer reviewed; Journal article, 2016-07-08)Background: The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ... -
Preoperative predictors of pathological tumour stage and prognosis may be used when selecting candidates for intensified treatment in upper tract urothelial carcinoma
Almås, Bjarte; Øverby, Stein; Halvorsen, Ole Johan; Reisæter, Lars Anders Rokne; Carlsen, Birgitte; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose: Intensified treatment such as extended lymph node dissection (LND) and/or perioperative chemotherapy in addition to radical nephroureterectomy (RNU) has been suggested for high-risk cases of upper tract urothelial ... -
Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC)
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Bostad, Leif; Hjelle, Karin; Aarstad, Hans Jørgen; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)Purpose An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family of cytokines at diagnosis were relevant to ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Eikrem, Øystein Solberg; Beisland, Christian; Hjelle, Karin Margrethe; Flatberg, Arnar; Scherer, Andreas; Landolt, Lea Zoe; Skogstrand, Trude; Leh, Sabine Maria; Beisvag, Vidar; Marti, Hans-Peter (Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ...