Browsing Bergen Open Research Archive by Author "Berven, Frode Steingrimsen"
Now showing items 1-14 of 14
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Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis
Mosleth, Ellen Færgestad; Vedeler, Christian Alexander; Liland, Kristian Hovde; McLeod, Anette; Bringeland, Gerd Haga; Kroondijk, Liesbeth; Berven, Frode Steingrimsen; Lysenko, Artem; Rawlings, Christopher J.; El-Hajj Eid, Karim; Opsahl, Jill Anette; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Gavasso, Sonia (Journal article; Peer reviewed, 2021-02-18)Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ... -
Comparing Efficiency of Lysis Buffer Solutions and Sample Preparation Methods for Liquid Chromatography–Mass Spectrometry Analysis of Human Cells and Plasma
Neset, Lasse; Takayidza, Gracious; Berven, Frode Steingrimsen; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2022)The use of a proper sample processing methodology for maximum proteome coverage and high-quality quantitative data is an important choice to make before initiating a liquid chromatography–mass spectrometry (LC–MS)-based ... -
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
Aasebø, Elise; Brenner, Annette; Birkeland, Even; Tvedt, Tor Henrik Anderson; Selheim, Frode; Berven, Frode Steingrimsen; Bruserud, Øystein (Journal article; Peer reviewed, 2021)Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem ... -
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis
Oveland, Eystein; Ahmad, Intakhar; Lereim, Ragnhild Reehorst; Kroksveen, Ann Cathrine; Barsnes, Harald; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Bø, Lars; Berven, Frode Steingrimsen; Wergeland, Stig (Journal article; Peer reviewed, 2021)Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ... -
Effects of the Autophagy-Inhibiting Agent Chloroquine on Acute Myeloid Leukemia Cells; Characterization of Patient Heterogeneity
Grønningsæter, Ida Sofie; Reikvam, Håkon; Aasebø, Elise; Bartaula-Brevik, Sushma; Hernandez‐valladares, Maria; Selheim, Frode; Berven, Frode Steingrimsen; Tvedt, Tor Henrik; Bruserud, Øystein; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2021)Autophagy is a highly conserved cellular degradation process that prevents cell damage and promotes cell survival, and clinical efforts have exploited autophagy inhibition as a therapeutic strategy in cancer. Chloroquine ... -
Human blood serum proteome changes after 6 hours of sleep deprivation at night
Bjørkum, Alvhild Alette; Duran, Ana Carasco; Berven, Frode Steingrimsen; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Peer reviewed, 2021)Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ... -
Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells
Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Mjaavatten, Olav; Reikvam, Håkon; Selheim, Frode; Berven, Frode Steingrimsen; Bruserud, Øystein (Journal article; Peer reviewed, 2021)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects. We investigated ... -
Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania
Barakat, Ahmed Samy Mohamed Ali; Birkeland, Even; Jørstad, Melissa Davidsen; el Hajj, Magalie; Marijani, Msafiri; Døskeland, Anne Marie Simonne; Mjaavatten, Olav; Berven, Frode Steingrimsen; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)This study aimed at exploring the proteomic profile of PBMCs to predict treatment response in pulmonary tuberculosis (PTB). This was a pilot study conducted among 8 adult patients from Zanzibar, Tanzania with confirmed ... -
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ... -
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ... -
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
Hernandez-Valladares, Maria; Wangen, Rebecca; Aasebø, Elise; Reikvam, Håkon; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
Yilmaz, Ozlem; Mangor-Jensen, Anders; Harboe, Torstein; Drønen, Margareth Møgster; Mangor-Jensen, Ragnfrid; Mjaavatten, Olav; Birkeland, Even; Spriet, Endy; Sandven, Linda; Furmanek, Tomasz; Berven, Frode Steingrimsen; Wargelius, Anna; Norberg, Birgitta (Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
Cappelletti, Chiara; Eriksson, Anna Maria; Brorson, Ina Skaara; Leikfoss, Ingvild Sørum; Glomstad Kråbøl, Oda; Høgestøl, Einar August; Vitelli, Valeria; Mjaavatten, Olav; Harbo, Hanne-Cathrin Flinstad; Berven, Frode Steingrimsen; Bos-Haugen, Steffan Daniel; Berge, Tone (Journal article; Peer reviewed, 2022-07-05)Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal ... -
Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity
Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ...