Blar i Bergen Open Research Archive på forfatter "Bettella, Francesco"
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Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations
Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Einevoll, Gaute (Peer reviewed; Journal article, 2019-02)Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ... -
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie (Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology
van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article; Peer reviewed, 2022)Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ... -
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik G.; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2018-10-02)The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ... -
Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2021)Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated ... -
Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes
O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Cheng, Weiqiu; Chu, Yunhan; Hindley, Guy; Lin, Aihua; Shadrin, Alexey; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Steen, Nils Eiel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)Background: A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ... -
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2019)Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ... -
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are ... -
Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders
Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ... -
Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort
Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2022)Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ... -
Enrichment of genetic markers of recent human evolution in educational and cognitive traits
Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-08-22)Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing ... -
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Peer reviewed; Journal article, 2019-10-22)Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ... -
GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-05-07)Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ... -
Genetic control of variability in subcortical and intracranial volumes
Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ... -
Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen; Frei, Oleksandr; Wirgenes, Katrine Verena; O`Connell, Kevin; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Sugrue, Leo P.; Wang, Yunpeng; Svenningsson, Per; Sharma, Manu; Pihlstrøm, Lasse; Toft, H. Mathias S.; O’Donovan, Michael; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M.; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)Background Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the ... -
Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ... -
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ... -
Identification of pleiotropy at the gene level between psychiatric disorders and related traits
Polushina, Tatiana; Banerjee, Niladri; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri J.; Djurovic, Srdjan; Cichon, Sven; Hoffmann, Per; Nöthen, Markus M.; Steen, Vidar Martin; Andreassen, Ole A.; Le Hellard, Stéphanie (Journal article; Peer reviewed, 2021)Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ... -
Identification of shared genetic variants between schizophrenia and lung cancer
Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-01-12)Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...