Blar i Bergen Open Research Archive på forfatter "Bezem, Maria Teresa"
-
Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles
Bezem, Maria Teresa; Johannessen, Fredrik Gullaksen; Kråkenes, Trond-André; Sailor, Michael J.; Martinez, Aurora (Journal article; Peer reviewed, 2021)Tyrosine hydroxylase (TH) is the enzyme catalyzing the rate-limiting step in the synthesis of dopamine in the brain. Developing enzyme replacement therapies using TH could therefore be beneficial to patient groups with ... -
Stabilisation of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy
Bezem, Maria Teresa (Master thesis, 2012-02-27)The aim of this thesis has been to characterise nanoparticles (NPs) to which tyrosine hydroxylase (TH) was attached, as a preliminary step in their evaluation to be used for an enzyme replacement therapy (ERT) for Parkinson's ... -
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset (Peer reviewed; Journal article, 2016-07-27)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ...