Blar i Bergen Open Research Archive på forfatter "Bjørnslett, Merete"
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Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
Bjørnslett, Merete; Knappskog, Stian; Lønning, Per Eystein; Dørum, Anne (Peer reviewed; Journal article, 2012-10-05)Background: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the ... -
MDM2 Promoter SNP344T>A (rs1196333) Status Does Not Affect Cancer Risk
Knappskog, Stian; Gansmo, Liv B.; Romundstad, Pål; Bjørnslett, Merete; Trovik, Jone; Lønning, Per Eystein; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012-04-30)The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been ...