Browsing Bergen Open Research Archive by Author "Bjørsvik, Hans-René"
Now showing items 1-6 of 6
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An environmentally benign and high-rate Appel type reaction
Fuenzalida, Nicolas Mattias del Rio; Alme, Eirin; Lundevall, Frida Johanne; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2022)A high rate, selective, and productive Appel type reaction was developed. The method allows for ipso-substitution of the alcoholic hydroxy group with halogens ∈ [Cl, Br, I]. The method demands mild reaction conditions that ... -
Functionalization of the Imidazole Backbone by Means of a Tailored and Optimized Oxidative Heck Cross-Coupling
Cirillo, Davide; Angelucci, Francesco; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2020)A general and selective Pd-catalyzed cross-coupling of aromatic boronic acids with vinyl-imidazoles is disclosed. Unlike most cross-coupling reactions, this method operates well in absence of bases avoiding the formation ... -
Imidazole Backbone Functionalization with Olefin Cross-Metathesis
Angelucci, Francesco; Cirillo, Davide; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2022)A selective and high-rate Ru-catalyzed cross-metathesis reaction of alkenes with vinylimidazole is disclosed. Cross-metathesis is known to operate less efficiently on N-heterocycles, but through optimization by means of ... -
A Scalable High-Yielding and Selective Oxidative Heck Cross-Coupling – A Key Step for the Synthesis of trans- Stilbenes
Cirillo, Davide; Karlsson, Staffan; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2021)A selective oxidative Heck cross-coupling method was developed and optimized as a pivotal step for a synthetic route leading to the trans-stilbene framework. The developed method and synthesis were needed in a SAR study ... -
Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors
Cirillo, Davide; Sarowar, Shahin; Enger, Per Øyvind; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2021)The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of ... -
The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis
Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo; Nilsen, Mette Hartmark; Otragane, Sarah-Muheha Anni; Heggdal, Jan Ingemann; Selheim, Frode; Ceña, Valentín; Bjørsvik, Hans-René; Enger, Per Øyvind (Journal article; Peer reviewed, 2022)Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ...