Browsing Bergen Open Research Archive by Author "Bjerkvig, Rolf"

Now showing items 1-20 of 45

    • Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...

    • AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion 

      Schuster, Anne; Klein, Eliane; Neirinckx, Virginie; Møldrup Knudsen, Arnon; Fabian, Carina; Hau, Ann-Christin; Dieterle, Monika; Oudin, Anaïs; Nazarov, Petr V.; Golebiewska, Anna; Muller, Arnaud; Perez-Hernandez, Daniel; Rhodius, Sophie; Dittmar, Gunnar; Bjerkvig, Rolf; Herold-Mende, Christel; Klink, Barbara; Winther Kristensen, Bjarne; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic ...

    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...

    • Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery 

      Lingasamy, Prakash; Tobi, Allan; Haugas, Maarja; Hunt, Hedi; Paiste, Paarn; Asser, Toomas; Ratsep, Tonu; Kotamraju, Venkata Ramana; Bjerkvig, Rolf; Teesalu, Tambet (Peer reviewed; Journal article, 2019)
      Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of ...

    • Cellular Host Responses to Gliomas 

      Najbauer, Joseph; Huszthy, Peter Csaba; Barish, Michael E.; Garcia, Elizabeth; Metz, Marianne Z.; Myers, Sarah M.; Gutova, Margarita; Frank, Richard T.; Miletic, Hrvoje; Kendall, Stephen E.; Glackin, Carlotta A.; Bjerkvig, Rolf; Aboody, Karen S. (Peer reviewed; Journal article, 2012-04-23)
      Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular ...

    • Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis 

      Aasen, Synnøve Nymark; Espedal, Heidi; Keunen, Olivier; Adamsen, Tom Christian Holm; Bjerkvig, Rolf; Thorsen, Frits (Journal article; Peer reviewed, 2021)
      Brain metastasis (BM) is a major cause of cancer patient morbidity. Clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) represent important resources to assess tumor progression and treatment ...

    • Deciphering the complex role of thrombospondin-1 in glioblastoma development 

      Daubon, Thomas; Léon, Céline; Clarke, Kim; Andrique, Laetitia; Salabert, Laura; Darbo, Elodie; Pineau, Raphael; Guérit, Sylvaine; Maitre, Marlène; Dedieu, Stéphane; Jeanne, Albin; Bailly, Sabine; Feige, Jean-Jacques; Miletic, Hrvoje; Rossi, Marco; Bello, Lorenzo; Falciani, Francesco; Bjerkvig, Rolf; Bikfalvi, Andréas (Peer reviewed; Journal article, 2019-03-08)
      We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased ...

    • Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors 

      Aasen, Synnøve Nymark; Parajuli, Himalaya; Hoang, Tuyen; Feng, Zichao; Stokke, Krister; Wang, Jiwei; Roy, Kislay; Bjerkvig, Rolf; Knappskog, Stian; Thorsen, Frits (Peer reviewed; Journal article, 2019-08-29)
      Malignant melanoma is the most aggressive type of skin cancer and is closely associated with the development of brain metastases. Despite aggressive treatment, the prognosis has traditionally been poor, necessitating ...

    • Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma 

      Svendsen, Agnete; Verhoeff, Joost J. C.; Immervoll, Heike; Brøgger, Jan C.; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger A.; Planagumà, Jesús; Torsvik, Anja; Sakariassen, Per Øystein; Bjerkvig, Rolf; Enger, Per Øyvind; Tronstad, Karl Johan (Peer reviewed; Journal article, 2011-08-24)
      Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ...

    • GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity 

      Watson, Dionysios C.; Bayik, Defne; Storevik, Simon Humberto; Moreino, Shannon Sherwin; Sprowls, Samuel A.; Han, Jianhua; Augustsson, Mina Thue; Lauko, Adam; Sravya, Palavalasa; Røsland, Gro Vatne; Troike, Katie; Tronstad, Karl Johan; Wang, Sabrina; Sarnow, Katharina; Kay, Kristen; Lunavat, Taral; Silver, Daniel J.; Dayal, Sahil; Vareecal Joseph, Justin; Mulkearns-Hubert, Erin; Ystaas, Lars Andreas Rømo; Deshpande, Gauravi; Guyon, Joris; Zhou, Yadi; Magaut, Capucine R.; Seder, Juliana; Neises, Laura; Williford, Sarah E.; Meiser, Johannes; Scott, Andrew J.; Sajjakulnukit, Peter; Mears, Jason A.; Bjerkvig, Rolf; Chakraborty, Abhishek; Daubon, Thomas; Cheng, Feixiong; Lyssiotis, Costas A.; Wahl, Daniel R.; Hjelmeland, Anita B.; Hossain, Md Jubayer al; Miletic, Hrvoje; Lathia, Justin D. (Journal article; Peer reviewed, 2023)
      The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly ...

    • Glioblastom hos voksne 

      Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Journal article; Peer reviewed, 2023)
      Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ...

    • Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes 

      Stieber, Daniel; Golebiewska, Anna; Evers, Lisa; Lenkiewicz, Elizabeth; Brons, Nicolas H.C.; Nicot, Nathalie; Oudin, Anaïs; Bougnaud, Sébastien; Hertel, Frank; Bjerkvig, Rolf; Vallar, Laurent; Barrett, Michael T.; Niclou, Simone P. (Peer reviewed; Journal article, 2014-02)
      Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ...

    • Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1 

      Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L. N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotar, Guillaume; Bjerkvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix (Journal article; Peer reviewed, 2021)
      Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...

    • Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors 

      Raa, Anette; Stansberg, Christine; Steen, Vidar Martin; Bjerkvig, Rolf; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Journal article, 2007-01-30)
      This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Methods: One group of animals was exposed to normobaric ...

    • Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection 

      El-Khoury, Victoria; Schritz, Anna; Kim, Sang-Yoon; Lesur, Antoine; Sertamo, Katriina; Bernardin, Francois; Petritis, Konstantinos; Pirrotte, Patrick; Selinsky, Cheryl; Whiteaker, Jeffrey R; Zhang, Haizhen; Kennedy, Jacob J; Lin, Chenwei; Lee, Lik Wee; Yan, Ping; Tran, Nhan L; Inge, Landon J; Chalabi, Khaled; Decker, Georges; Bjerkvig, Rolf; Paulovich, Amanda G; Berchem, Guy; Kim, Yeoun Jin (Journal article; Peer reviewed, 2020)
      Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ...

    • In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways 

      Daphu, Inderjit Kaur; Horn, Sindre August; Stieber, Daniel; Varughese, Jobin K.; Spriet, Endy; Dale, Hege Avsnes; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Thorsen, Frits Alan (Peer reviewed; Journal article, 2014-05-16)
      Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAFV600E mutation, which activates the mitogen-activated protein kinase ...

    • Inference of low and high-grade glioma gene regulatory networks delineates the role of Rnd3 in establishing multiple hallmarks of cancer 

      Clarke, Kim; Daubon, Thomas; Turan, Nil; Soulet, Fabienne; Mohd Zahari, Maihafizah; Ryan, Katie R.; Durant, Sarah; He, Shan; Herbert, John; Ankers, John; Heath, John K.; Bjerkvig, Rolf; Bicknell, Roy; Hotchin, Neil A.; Bikfalvi, Andreas; Falciani, Francesco (Peer reviewed; Journal article, 2015-07-01)
      Gliomas are a highly heterogeneous group of brain tumours that are refractory to treatment, highly invasive and pro-angiogenic. Glioblastoma patients have an average survival time of less than 15 months. Understanding the ...

    • Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes 

      Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)
      Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...

    • Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis 

      Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)
      Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ...

    • Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling 

      Han, Mingzhi; Wang, Shuai; Fritah, Sabrina; Wang, Xu; Zhou, Wenjing; Yang, Ning; Ni, Shilei; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2020)
      Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-5p, is ranked among the most ...