Browsing Bergen Open Research Archive by Author "Bjune, Jan Inge"
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Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)
Madsen, Andre; Bozickovic, Olivera; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. (Peer reviewed; Journal article, 2015-11-09)The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 ...