Browsing Bergen Open Research Archive by Author "Bohlin, Jon"

Now showing items 1-13 of 13

    • Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry 

      Bohlin, Jon; Page, Christian Magnus; Lee, Yunsung; Pettersson, John H.-O.; Jugessur, Astanand; Magnus, Per Minor; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2022)
      Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina ...

    • Associations between epigenetic age acceleration and infertility 

      Lee, Yunsung; Bohlin, Jon; Page, Christian Magnus; Nustad, Haakon E.; Harris, Jennifer Ruth; Magnus, Per Minor; Magnus, Per; Jugessur, Astanand; Magnus, Maria Christine; Håberg, Siri Eldevik; Hanevik, Hans Ivar (Journal article; Peer reviewed, 2022)
      Study question: Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? Summary answer: The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed ...

    • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 

      Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)
      Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ...

    • Cross-fitted instrument: A blueprint for one-sample Mendelian randomization 

      Denault, William Robert Paul; Bohlin, Jon; Page, Christian Magnus; Burgess, Stephen; Jugessur, Astanand (Journal article; Peer reviewed, 2022-08-29)
      Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new ...

    • DNA methylation in newborns conceived by assisted reproductive technology 

      Håberg, Siri Eldevik; Page, Christian Magnus; Lee, Yunsung; Nustad, Haakon Egdetveit; Magnus, Maria Christine; Haftorn, Kristine Løkås; Carlsen, Ellen Øen; Denault, William Robert Paul; Bohlin, Jon; Jugessur, Astanand; Magnus, Per Minor; Gjessing, Håkon Kristian; Lyle, Robert (Journal article; Peer reviewed, 2022)
      Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ...

    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...

    • Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography 

      Kristjansson, Dana; Bohlin, Jon; Nguyen, Truc Trung; Jugessur, Astanand; Schurr, Theodore G. (Journal article; Peer reviewed, 2022)
      Background: We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial ...

    • Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium 

      Sharp, Gemma C; Salas, Lucas A; Monnereau, Claire; Bohlin, Jon; Page, Christian; Lie, Rolv T.; Magnus, Maria Christine; Munthe-Kaas, Monica Cheng; Nystad, Wenche (Peer reviewed; Journal article, 2017-10)
      Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the ...

    • Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns 

      Joubert, Bonnie R; Den Dekker, Herman T; Felix, Janine F; Bohlin, Jon; Ligthart, Symen; Beckett, Emma; Tiemeier, Henning; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Håberg, Siri Eldevik; Reese, Sarah E; Peters, Marjolein J; Kulle Andreassen, Bettina; Steegers, Eric A P; Nilsen, Roy Miodini; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Franco, Oscar H; Dehghan, Abbas; De Jongste, Johan C; Wu, Michael C; Wang, Tianyuan; Peddada, Shyamal D; Jaddoe, Vincent W V; Nystad, Wenche; Duijts, Liesbeth; London, Stephanie J (Peer reviewed; Journal article, 2016-02-10)
      Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development ...

    • Matrilineal diversity and population history of Norwegians 

      Kristjansson, Dana; Bohlin, Jon; Jugessur, Astanand; Schurr, Theodore G. (Journal article; Peer reviewed, 2021)
      Background: While well known for its Viking past, Norway's population history and the influences that have shaped its genetic diversity are less well understood. This is particularly true with respect to its demography, ...

    • Nucleated red blood cells explain most of the association between DNA methylation and gestational age 

      Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ...

    • Phylogeographic history of mitochondrial haplogroup J in Scandinavia 

      Kristjansson, Dana; Schurr, Theodore; Bohlin, Jon; Jugessur, Astanand (Journal article, 2023)
      Background: Mitochondrial DNA haplogroup J is the third most frequent haplogroup in modern-day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined ...

    • Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels 

      Lee, Yunsung; Choufani, Sanaa; Weksberg, Rosanna; Wilson, Samantha L.; Yuan, Victor; Burt, Amber; Marsit, Carmen; Lu, Ake T.; Ritz, Beate; Bohlin, Jon; Gjessing, Håkon K.; Harris, Jennifer Ruth; Magnus, Per; Binder, Alexandra M.; Robinson, Wendy P.; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)
      The human pan-tissue epigenetic clock is widely used for estimating age across the entire lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental DNAm methylation (DNAm) data. We ...