Browsing Bergen Open Research Archive by Author "Brügger, Kim"
Now showing items 1-4 of 4
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Development and validation of a universal blood donor genotyping platform: A multinational prospective study
Gleadall, Nicholas S.; Veldhuisen, Barbera; Gollub, Jeremy; Butterworth, Adam S.; Ord, John; Penkett, Christopher J.; Timmer, Tiffany C.; Sauer, Carolin M.; Van Der Bolt, Nieke; Brown, Colin; Brügger, Kim; Dilthey, Alexander T.; Duarte, Daniel; Grimsley, Shane; Van Den Hurk, Katja; Jongerius, John M.; Luken, Jessie; Megy, Karyn; Miflin, Gail; Nelson, Christopher S.; Prinsze, Femmeke J.; Sambrook, Jennifer; Simeoni, Ilenia; Sweeting, Michael; Thornton, Nicole; Trompeter, Sara; Tuna, Salih; Varma, Ram; Walker, Matthew R.; Danesh, John; Roberts, David J.; Ouwehand, Willem H.; Stirrups, Kathleen E.; Rendon, Augusto; Westhoff, Connie M.; Di Angelantonio, Emanuele; van der Schoot, C. Ellen; Astle, William J.; Watkins, Nicholas A.; Lane, William J. (Journal article; Peer reviewed, 2020)Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non–self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor ... -
DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease
Gaare, Johannes Jernqvist; Brügger, Kim; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)Background Epigenetic clocks using DNA methylation (DNAm) to estimate biological age have become popular tools in the study of neurodegenerative diseases. Notably, several recent reports have shown a strikingly similar ... -
Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease
Gaare, Johannes Jernqvist; Dölle, Christian; Brakedal, Brage; Brügger, Kim; Haugarvoll, Kristoffer; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in models of aging and neurodegenerative diseases, including Parkinson’s ... -
One byte at a time: evidencing the quality of clinical service next-generation sequencing for germline and somatic variants
Gutowska-Ding, Maria Weronika; Deans, Zandra C.; Roos, Christophe; Matilainen, Jukka; Khawaja, Farrah; Brügger, Kim; Ahn, Jo Wook; Boustred, Christopher; Patton, Simon J. (Journal article; Peer reviewed, 2020)Next-generation sequencing (NGS) is replacing other molecular techniques to become the de facto gene diagnostics approach, transforming the speed of diagnosis for patients and expanding opportunities for precision medicine. ...