Blar i Bergen Open Research Archive på forfatter "Brügger, Kim"

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    • Development and validation of a universal blood donor genotyping platform: A multinational prospective study 

      Gleadall, Nicholas S.; Veldhuisen, Barbera; Gollub, Jeremy; Butterworth, Adam S.; Ord, John; Penkett, Christopher J.; Timmer, Tiffany C.; Sauer, Carolin M.; Van Der Bolt, Nieke; Brown, Colin; Brügger, Kim; Dilthey, Alexander T.; Duarte, Daniel; Grimsley, Shane; Van Den Hurk, Katja; Jongerius, John M.; Luken, Jessie; Megy, Karyn; Miflin, Gail; Nelson, Christopher S.; Prinsze, Femmeke J.; Sambrook, Jennifer; Simeoni, Ilenia; Sweeting, Michael; Thornton, Nicole; Trompeter, Sara; Tuna, Salih; Varma, Ram; Walker, Matthew R.; Danesh, John; Roberts, David J.; Ouwehand, Willem H.; Stirrups, Kathleen E.; Rendon, Augusto; Westhoff, Connie M.; Di Angelantonio, Emanuele; van der Schoot, C. Ellen; Astle, William J.; Watkins, Nicholas A.; Lane, William J. (Journal article; Peer reviewed, 2020)
      Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non–self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor ...

    • DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease 

      Gaare, Johannes Jernqvist; Brügger, Kim; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)
      Background Epigenetic clocks using DNA methylation (DNAm) to estimate biological age have become popular tools in the study of neurodegenerative diseases. Notably, several recent reports have shown a strikingly similar ...

    • Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease 

      Gaare, Johannes Jernqvist; Dölle, Christian; Brakedal, Brage; Brügger, Kim; Haugarvoll, Kristoffer; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)
      Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in models of aging and neurodegenerative diseases, including Parkinson’s ...

    • One byte at a time: evidencing the quality of clinical service next-generation sequencing for germline and somatic variants 

      Gutowska-Ding, Maria Weronika; Deans, Zandra C.; Roos, Christophe; Matilainen, Jukka; Khawaja, Farrah; Brügger, Kim; Ahn, Jo Wook; Boustred, Christopher; Patton, Simon J. (Journal article; Peer reviewed, 2020)
      Next-generation sequencing (NGS) is replacing other molecular techniques to become the de facto gene diagnostics approach, transforming the speed of diagnosis for patients and expanding opportunities for precision medicine. ...