Browsing Bergen Open Research Archive by Author "Brede, Cato"
Now showing items 1-10 of 10
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Cytotoxic Natural Products from the Jurassic Relict Osmunda regalis L.
Carpinteyro Diaz, Andrea Estefania; Herfindal, Lars; Holmelid, Bjarte; Brede, Cato; Andersen, Heidi Lie; Vedeler, Anni; Fossen, Torgils (Journal article; Peer reviewed, 2024)The Jurassic relict Royal fern, Osmunda regalis L., is widely distributed across temperate zones in the Northern and Southern hemispheres. Even though this species has been utilised for centuries as a medicinal plant, its ... -
Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies
Uleberg, Kai-Erik; Munk, Ane Cecilie; Brede, Cato; Gudlaugsson, Einar; Diermen, Bianca van; Skaland, Ivar; Malpica, Anais; Janssen, Emilius Adrianus Maria; Hjelle, Anne; Baak, Jan P. A. (Peer reviewed; Journal article, 2011-06-28)Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ... -
Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid
Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Journal article; Peer reviewed, 2019)Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ... -
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Journal article; Peer reviewed, 2023)Background: The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ... -
Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia
Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato; Lauritzen, Trine; Aukrust, Pål; Steinsvik, Trude; Husebye, Einar; Michelsen, Annika; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2021)Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in ... -
Hepcidin predicts 5-year mortality after community-acquired pneumonia
Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2022)Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Journal article; Peer reviewed, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein
Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Journal article; Peer reviewed, 2021)Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ... -
Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina
Næsgaard, Patrycja A.; Fuente, Ricardo León de la; Nilsen, Stein Tore; Woie, Leik; Aarsland, Torbjørn; Brede, Cato; Staines, Harry; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2012-09-06)Background: Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum. Methods: We assessed the ... -
Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Peer reviewed; Journal article, 2019)Background: Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...