Blar i Bergen Open Research Archive på forfatter "Bredholt, Therese"
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Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Delineating cellular and molecular mechanisms of toxicity of an extract of khat (Catha edulis Forsk.) in leukemia and normal peripheral blood cells
Bredholt, Therese (Doctoral thesis, 2010-05-07)Plants have been used in treatment and prevention of diseases for thousands of years. In modern medicine there is a trend towards isolation and identification of bioactive molecules, whereas plant preparations continue to ... -
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ... -
Stathmin Protein Level, a Potential Predictive Marker for Taxane Treatment Response in Endometrial Cancer
Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø; Wik, Elisabeth; Akslen, Lars A.; Birkeland, Even; Bredholt, Therese; Tangen, Ingvild Løberg; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-02-25)Stathmin is a prognostic marker in many cancers, including endometrial cancer. Preclinical studies, predominantly in breast cancer, have suggested that stathmin may additionally be a predictive marker for response to ...