• Aquaporin evolution in fishes 

      Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2011-07-26)
      Aquaporins represent a primordial group of transmembrane solvent channels that have been documented throughout the living biota. This facet alone emphasizes the positive selection pressure for proteins associated with ...
    • Auto-Adhesion Potential of Extraocular Aqp0 during Teleost Development 

      Chauvigné, Francois; Fjelldal, Per Gunnar; Cerdà, Joan; Finn, Roderick Nigel (Peer reviewed; Journal article, 2016-05-06)
      AQP0 water channels are the most abundant proteins expressed in the mammalian lens fiber membranes where they are essential for lens development and transparency. Unlike other aquaporin paralogs, mammalian AQP0 has a low ...
    • Insect glycerol transporters evolved by functional co-option and gene replacement 

      Finn, Roderick Nigel; Chauvigné, Francois; Stavang, Jon Anders; Belles, Xavier; Cerdà, Joan (Peer reviewed; Journal article, 2015-07-17)
      Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable ...
    • The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation 

      Finn, Roderick Nigel; Chauvigné, Francois; Hlidberg, Jón Baldur; Cutler, Christopher P.; Cerdà, Joan (Peer reviewed; Journal article, 2014-11-26)
      A major physiological barrier for aquatic organisms adapting to terrestrial life is dessication in the aerial environment. This barrier was nevertheless overcome by the Devonian ancestors of extant Tetrapoda, but the origin ...
    • Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility 

      Chauvigné, François; Boj, Mónica; Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2015-01-14)
      Reactive oxygen species (ROS), particularly hydrogen peroxide (H2O2), cause oxidative cell damage and inhibit sperm function. In most oviparous fishes that spawn in seawater (SW), spermatozoa may be exposed to harmful ROS ...
    • The pH sensitivity of Aqp0 channels in tetraploid and diploid teleosts 

      Chauvigné, Francois; Zapater, Cinta; Stavang, Jon Anders; Taranger, Geir Lasse; Cerdà, Joan; Finn, Roderick Nigel (Peer reviewed; Journal article, 2015)
      Water homeostasis and the structural integrity of the vertebrate lens is partially mediated by AQP0 channels. Emerging evidence indicates that external pH may be involved in channel gating. Here we show that a tetraploid ...
    • Phylogenomic and functional analyses of salmon lice aquaporins uncover the molecular diversity of the superfamily in Arthropoda 

      Stavang, Jon Anders; Chauvigné, Francois; Kongshaug, Heidi; Cerdà, Joan; Nilsen, Frank; Finn, Roderick Nigel (Peer reviewed; Journal article, 2015-08-19)
      Background An emerging field in biomedical research is focusing on the roles of aquaporin water channels in parasites that cause debilitating or lethal diseases to their vertebrate hosts. The primary vectorial agents are ...
    • Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters 

      Yilmaz, Ozlem; Chauvigné, Francois; Ferré, Alba; Nilsen, Frank; Fjelldal, Per Gunnar; Cerdà, Joan; Finn, Roderick Nigel (Journal article; Peer reviewed, 2020)
      Transmembrane glycerol transport is an ancient biophysical property that evolved in selected subfamilies of water channel (aquaporin) proteins. Here, we conducted broad level genome (>550) and transcriptome (>300) analyses ...
    • The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter 

      Chauvigné, Francois; Yilmaz, Ozlem; Ferré, Alba; Fjelldal, Per Gunnar; Finn, Roderick Nigel; Cerdà, Joan (Peer reviewed; Journal article, 2019-12-11)
      Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in ...
    • The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals 

      Tingaud-Sequeira, Angèle; Calusinska, Magdalena; Finn, Roderick Nigel; Chauvigné, François; Lozano, Juanjo; Cerdà, Joan (Peer reviewed; Journal article, 2010-02-11)
      Background: Aquaporins are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. These proteins are vital for maintaining water homeostasis in living organisms. In ...