Browsing Bergen Open Research Archive by Author "Chekenya, Martha"
Now showing items 1-16 of 16
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Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies
Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Peer reviewed; Journal article, 2007-11)Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ... -
Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma
Kmiecik, Justyna; Gras Navarro, Andrea; Poli, Aurélie; Planaguma, Jesus; Zimmer, Jacques; Chekenya, Martha (Peer reviewed; Journal article, 2014)Glioblastoma is a deadly brain cancer with limited treatment options. Targeting chondroitin sulfate proteoglycan 4 (CSPG4, best known as NG2) with the monoclonal antibody mAb9.2.27 and activated natural killer (NK) cells ... -
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma
Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2014-09-30)There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and ... -
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level
Kmiecik, Justyna; Poli, Aurélie; Brons, Nicolaas H.C.; Waha, Andreas; Eide, Geir Egil; Enger, Per Øyvind; Zimmer, Jacques; Chekenya, Martha (Peer reviewed; Journal article, 2013-11-15)We characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell ... -
Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model
Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind (Peer reviewed; Journal article, 2013)Object. Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs). However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of ... -
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2012-01-17)Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ... -
Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2009-07-28)Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-be ... -
Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours
Kmiecik, Justyna; Zimmer, Jacques; Chekenya, Martha (Peer reviewed; Journal article, 2014-01)Natural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in ... -
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival
Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik; Zelkowski, Mateusz; Engelsen, Agnete; Bruserud, Øystein; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2014-12)Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms ... -
Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting
Poli, Aurélie; Brons, Nicolaas H.C.; Ammerlaan, Wim; Michel, Tatiana; Hentges, François; Chekenya, Martha; Zimmer, Jacques (Peer reviewed; Journal article, 2010-11)Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ... -
A reproducible brain tumour model established from human glioblastoma biopsies
Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekkå, Narve; Li, Xingang; Zhao, Peng; Mørk, Sverre; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind (Peer reviewed; Journal article, 2009-12-29)Background: Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ... -
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
Krakstad, Camilla; Chekenya, Martha (Peer reviewed; Journal article, 2010-06-01)Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy with ... -
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planagumà, Jesús; Yan, Tao; Rygh, Cecilie Brekke; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2013-09-09)Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet need ... -
Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma
Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planagumà, Jesús; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Rygh, Cecilie Brekke; Chekenya, Martha (Peer reviewed; Journal article, 2011-07-29)Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including ... -
Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
Gras Navarro, Andrea; Björklund, Andreas T.; Chekenya, Martha (Peer reviewed; Journal article, 2015-04-29)Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring one-to-one target engagement and ...