Browsing Bergen Open Research Archive by Author "Cimpan, Mihaela-Roxana"

Now showing items 1-9 of 9

    • Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models 

      Buociková, Verona; Longhin, Eleonora Marta; Pilalis, Eleftherios; Mastrokalou, Chara; Miklíková, Svetlana; Cihova, Marina; Poturnayova, Alexandra; Mackova, Katarina; Bábelová, Andrea; Trnkova, Lenka; El Yamani, Naouale; Zheng, Congying; Rios-Mondragon, Ivan; Labudova, Martina; Csaderova, Lucia; Kuracinova, Kristina Mikus; Makovicky, Peter; Kučerová, Lucia; Matuskova, Miroslava; Cimpan, Mihaela-Roxana; Dusinska, Maria; Babal, Pavel; Chatziioannou, Aristotelis; Gábelová, Alena; Rundén-Pran, Elise; Smolkova, Bozena (Journal article; Peer reviewed, 2022)
      Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ...

    • Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression 

      Buociková, Verona; Tyciakova, Sylvia; Pilalis, Eleftherios; Mastrokalou, Chara; Urbanova, Maria; Matuskova, Miroslava; Demkova, Lucia; Medova, Veronika; Longhin, Eleonora Marta; Rundén-Pran, Elise; Dusinska, Maria; Rios Mondragon, Ivan; Cimpan, Mihaela-Roxana; Gábelová, Alena; Soltysova, Andrea; Smolkova, Bozena; Chatziioannou, Aristotelis (Journal article; Peer reviewed, 2022)
      Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising ...

    • Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction 

      Das, Ridhima; Harper, Lisa; Kitajima, Kayoko; Osman, Tarig Al-Hadi; Cimpan, Mihaela-Roxana; Johannessen, Anne Christine; Suliman, Salwa; Mackenzie, Ian C.; Costea, Daniela Elena (Journal article; Peer reviewed, 2023)
      We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ...

    • Hazard assessment of nanomaterials using in vitro toxicity assays: Guidance on potential assay interferences and mitigating actions to avoid biased results 

      El Yamani, Naouale; Rundén-Pran, Elise; Varet, Julia; Beus, Maja; Dusinska, Maria; Fessard, Valerie; Moschini, Elisa; Serchi, Tommaso; Cimpan, Mihaela-Roxana; Lynch, Iseult; Vinković Vrček, ivana (Journal article; Peer reviewed, 2024)
      The movement towards an animal-free testing approach for risk assessment represents a key paradigm shift in toxicology. Risk assessment of engineered and anthropogenic nanoscale materials (NM) is dependent on reliable ...

    • Isolation of TiNbN wear particles from a coated metal-on-metal bearing: Morphological characterization and in vitro evaluation of cytotoxicity in human osteoblasts 

      Sellin, Marie-Luise; Seyfarth-Sehlke, Anika; Aziz, Mahammad; Fabry, Christian; Wenke, Katrin; Høl, Paul Johan; Rios Mondragon, Ivan; Cimpan, Mihaela-Roxana; Frank, Marcus; Bader, Rainer; Jonitz-Heincke, Anika (Journal article; Peer reviewed, 2024)
      To improve the wear resistance of articulating metallic joint endoprostheses, the surfaces can be coated with titanium niobium nitride (TiNbN). Under poor tribological conditions or malalignment, wear can occur on these ...

    • Linking Nanomaterial-Induced Mitochondrial Dysfunction to Existing Adverse Outcome Pathways for Chemicals 

      Murugadoss, Sivakumar; Vrček, Ivana Vinković; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela-Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H. (Journal article; Peer reviewed, 2024)
      The Adverse Outcome Pathway (AOP) framework plays a crucial role in the paradigm shift of toxicity testing towards the development and use of new approach methodologies. AOPs developed for chemicals are in theory applicable ...

    • Polycrystalline Diamond Coating on Orthopedic Implants: Realization and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation 

      Zalieckas, Justas; Rios Mondragon, Ivan; Pobedinskas, Paulius; Kristoffersen, Arne Skodvin; Mohamed-Ahmed, Samih; Gjerde, Cecilie; Høl, Paul Johan; Hallan, Geir; Furnes, Ove Nord; Cimpan, Mihaela-Roxana; Haenen, Ken; Holst, Bodil; Greve, Martin Møller (Journal article; Peer reviewed, 2022)
      Polycrystalline diamond has the potential to improve the osseointegration of orthopedic implants compared to conventional materials such as titanium. However, despite the excellent biocompatibility and superior mechanical ...

    • Predicting intention of Norwegian dental health-care workers to use nanomaterials: An application of the augmented theory of planned behavior 

      Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena; Breivik, Kyrre; Lie, Stein Atle; Cimpan, Mihaela-Roxana; Åstrøm, Anne-Kristine N (Journal article; Peer reviewed, 2021)
      Due to the rapid development of nanotechnology and its integration into dentistry, there is a need for information on the factors influencing the decision of dental health-care workers to use nanomaterials. Based on a ...

    • A strategy towards the generation of testable adverse outcome pathways for nanomaterials 

      Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H. (Journal article; Peer reviewed, 2021)
      Manufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are ...