Blar i Bergen Open Research Archive på forfatter "Costea, Daniela Elena"
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Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival
Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ... -
Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics
Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Costea, Daniela Elena; Søland, Tine Merete; Galtung, Hilde (Journal article; Peer reviewed, 2020-09-04)Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ... -
Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Ahmed, Israa A.H.; Elsheikh, Mariam; Dongre, Harsh Nitin; Jacobsen, Martha Rolland; Mohamed, Nazar; Fromreide, Siren; Suleiman, Ahmed Mohamed; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Background Tumor immune infiltrate has been explored in oral squamous cell carcinoma (OSCC), but studies on simultaneous characterization of multiple immune cell subtypes separately in stromal and intraepithelial tumor ... -
Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena; Berg, Eli; Cavalcanti Jacobsen, Cristiane de Albuquerque; Mortensen, Bente; Salo, Tuula; Martinez, Inigo Zubiavrre; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg (Peer reviewed; Journal article, 2017-05-19)Background: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously ... -
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma
Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2014-10-04)Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ... -
A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Peer reviewed, 2020-06-30)We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the ... -
Combined in situ hybridization and immunohistochemistry on archival tissues reveals stromal microRNA-204 as prognostic biomarker for oral squamous cell carcinoma
Rajthala, Saroj; Dongre, Harsh; Parajuli, Himalaya; Min, Anjie; Nginamau, Elisabeth Sivy; Kvalheim, Arild; Lybak, Stein; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Micro-RNAs (miRs) are emerging as important players in carcinogenesis. Their stromal expression has been less investigated in part due to lack of methods to accurately differentiate between tumor compartments. This study ... -
Combined loss of expression of involucrin and cytokeratin 13 is associated with poor prognosis in squamous cell carcinoma of mobile tongue
Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi; Sand, Lars Peter; Petersen, Fernanda Cristina; Costea, Daniela Elena; Senguven, Burcu; Sapkota, Dipak (Journal article; Peer reviewed, 2021)Background This study aimed to evaluate the prognostic significance of expression levels of involucrin (IVL), cytokeratin (CK)-10 and -13 at different intratumor sites (tumor center and invading area) of oral tongue ... -
Degenerative bony changes in the temporal component of the temporomandibular joint – review of the literature
Vîrlan, Maria Justina Roxana; Costea, Daniela Elena; Păun, Diana Loreta; Zamfir-Chiru-anton, Adina; Sterian, Alin Gabriel; Spînu, Arsenie Dan; Nimigean, Victor; Nimigean, Vanda Roxana (Journal article; Peer reviewed, 2022)Temporomandibular joint (TMJ) changes are quite frequent in adults, but not all changes are degenerative. A high prevalence of bone alterations in the TMJs was reported by different research groups. Disturbed remodeling ... -
Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs
Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Yassin, Mohammed Ahmed Alamin Yousif; Dongre, Harsh Nitin; Costea, Daniela Elena; Tangl, Stefan; Stavropoulos, Andreas; Bolstad, Anne Isine; Suliman, Salwa; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021-11-30)Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). Gingiva-derived progenitor cells (GPC) represent a less invasive alternative ... -
Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography
Guerreiro, Eduarda; Vestad, Beate; Steffensen, Lilly Alice; Aass, Hans Christian Dalsbotten; Saeed, Muhammad; Øvstebø, Reidun; Costea, Daniela Elena; Galtung, Hilde; Søland, Tine Merete (Peer reviewed; Journal article, 2018-09-27)Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source of potential biomarkers for early detection of diseases such as cancer. However, ... -
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
Ando, Toshinori; Arang, Nadia; Wang, Zhiyong; Costea, Daniela Elena; Feng, Xiaodong; Goto, Yusuke; Izumi, Hiroki; Gilardi, Mara; Ando, Kazuyo; Gutkind, J. Silvio (Journal article; Peer reviewed, 2021)The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ activation in ... -
Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction
Das, Ridhima; Harper, Lisa; Kitajima, Kayoko; Osman, Tarig Al-Hadi; Cimpan, Mihaela-Roxana; Johannessen, Anne Christine; Suliman, Salwa; Mackenzie, Ian C.; Costea, Daniela Elena (Journal article; Peer reviewed, 2023)We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ... -
Epithelial PD-L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Elsheikh, Mariam; Alhaj Ahmed, Israa Abdul Rhman Hassaballah; Dongre, Harsh Nitin; Fromreide, Siren; Suleiman, Ahmed M.; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active ... -
Epithelial-mesenchymal interactions in normal and neoplastic human oral mucosa. A study on in vitro organotypic models
Costea, Daniela Elena (Doctoral thesis, 2005-04-15)Epithelial-mesenchymal interactions are necessary for the development of oral epithelium during embryogenesis, but adult oral epithelium is also under the influence of mesenchymal tissue in both normal and neoplastic ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential
Dongre, Harsh; Rana, Neha; Fromreide, Siren; Rajthala, Saroj; Engelsen, Ingeborg Bøe; Paradis, Justine; Gutkind, J. Silvio; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Bjørge, Line; Costea, Daniela Elena (Journal article; Peer reviewed, 2020)Vulvar squamous cell carcinoma associated with lichen sclerosus (VLS-VSCC) are rare tumors but with higher recurrence and worse prognosis than other types of VSCC. Lack of experimental models has limited the search for ... -
Feasibility of a portable electronic nose for detection of oral squamous cell carcinoma in sudan
Mohamed, Nazar; van de Goor, Rens; El-Sheikh, Mariam; Elrayah, Osman; Osman, Tarig; Nginamau, Elisabeth Sivy; Johannessen, Anne Christine; Suleiman, Ahmed; Costea, Daniela Elena; Kross, Kenneth W. (Journal article; Peer reviewed, 2021-05-03)Background: Oral squamous cell carcinoma (OSCC) is increasing at an alarming rate particularly in low-income countries. This urges for research into noninvasive, user-friendly diagnostic tools that can be used in ... -
Granulocyte macrophage-colony stimulating factor and keratinocyte growth factor control of early stages of differentiation of oral epithelium
Das, Ridhima; Virlan, Maria Justina Roxana; Xenaki, Victoria; Kulasekara, Keerthi Kumara; Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Calenic, Bogdan; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Oral epithelial differentiation is known to be directed by underlying fibroblasts, but the responsible factor(s) have not been identified. We aimed here to identify fibroblast-derived factors responsible for oral epithelial ... -
Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients
Pandey, Sushma; Follin-Arbelet, Benoit; Bahadur Pun, Chin; K. Gautam, Dej; Johannessen, Anne Christine; Petersen, Fernanda Cristina; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Peer reviewed, 2020)Helicobacter pylori (HP) infection is an established causative agent for gastric cancer. Although the oral cavity is a part of the gastrointestinal system, the presence and possible causative role of HP in oral squamous ...