Browsing Bergen Open Research Archive by Author "Cox, Rebecca Jane"

Now showing items 1-20 of 63

    • Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self-reported severity and duration of illness 

      Tunheim, Gro; Laake, Ida; Robertson, Anna Hayman; Waalen, Kristian; Hungnes, Olav; Næss, Lisbeth Meyer; Cox, Rebecca Jane; Mjaaland, Siri; Trogstad, Lill (Peer reviewed; Journal article, 2018-12-09)
      Background: A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. Objectives: We studied maternal ...

    • Assay harmonization and use of biological standards to improve the reproducibility of the hemagglutination inhibition assay: A FLUCOP collaborative study 

      Waldock, Joanna; Zheng, Lingyi; Remarque, Edmond J.; Civet, Alexandre; Hu, Branda; Jalloh, Sarah Larteley Lartey; Cox, Rebecca Jane; Ho, Sammy; Höschler, Katja; Ollinger, Thierry; Trombetta, Claudia Maria; Engelhardt, Othmar; Caillet, Catherine (Journal article; Peer reviewed, 2021)
      The hemagglutination inhibition (HAI) assay is an established technique for assessing influenza immunity, through measurement of antihemagglutinin antibodies. Improved reproducibility of this assay is required to provide ...

    • Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study 

      Kuwelker, Kanika; Zhou, Fan; Blomberg, Bjørn; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Krammer, Florian; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Linchausen, Dagrunn Waag; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)
      Background Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission. We hypothesise that seropositivity provides more ...

    • Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years 

      Trieu, Mai Chi; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Sridhar, Saranya; Mjaaland, Siri; Cox, Rebecca Jane (Peer reviewed; Journal article, 2018-08-14)
      Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ...

    • Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination 

      Mohn, Kristin Greve-Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Peer reviewed; Journal article, 2017-05)
      Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ...

    • Common nodes of virus-host interaction revealed through an integrated network analysis 

      Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2019-10-04)
      Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...

    • Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination 

      Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)
      Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ...

    • Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy 

      Savic, Miloje; Dembinski, Jennifer Lynn; Laake, Ida; Hungnes, Olav; Cox, Rebecca Jane; Oftung, Fredrik; Trogstad, Lill; Mjaaland, Siri (Peer reviewed; Journal article, 2017-11-16)
      Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ...

    • A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza 

      Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Peer reviewed; Journal article, 2017-12)
      Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ...

    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...

    • Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients 

      Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Zhou, Fan; Madsen, Anders Aasgaard; Onyango, Therese Bredholt; Fjelltveit, Elisabeth Berg; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Cantoni, Diego; Mayora-Neto, Martin; Temperton, Nigel; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ...

    • Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Islam, Shahinul; Oftung, Fredrik; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ...

    • Enhancing Public Health Communication Regarding Vaccine Trials: Design and Development of the Pan-European VACCELERATE Toolkit 

      Argyropoulos, Christos D.; Leckler, Janina; Salmanton-García, Jon; Constantinou, Marinos; Alexandrou, Alexandra; Themistocleous, Sophia; Noula, Evgenia; Shiamakkides, George; Nearchou, Andria; Stewart, Fiona A.; Albus, Kerstin; Koniordou, Markela; Kopsidas, Ioannis; Spivak, Orly; Hellemans, Margot; Hendrickx, Greet; Davis, Ruth Joanna; Azzini, Anna Maria; Simon, Paula Valle; Carcas-Sansuan, Antonio Javier; Askling, Helena Hervius; Vene, Sirkka; Prellezo, Jana Baranda; Álvarez-Barco, Elena; Macken, Alan J.; Di Marzo, Romina; Luís, Catarina; Olesen, Ole F.; Frias Iniesta, Jesus A.; Barta, Imre; Tóth, Krisztina; Akova, Murat; Bonten, Marc M.J.; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Součková, Lenka; Husa, Petr; Jancoriene, Ligita; Launay, Odile; Lundgren, Jens; Mallon, Patrick; Armeftis, Charis; Marques, Laura; Naucler, Pontus; Ochando, Jordi; Tacconelli, Evelina; van Damme, Pierre; Zaoutis, Theoklis; Hofstraat, Sanne; Bruijning-Verhagen, Patricia; Zeitlinger, Markus; Cornely, Oliver A.; Pana, Zoi Dorothea (Journal article; Peer reviewed, 2023)
      Background: The pan-European VACCELERATE network aims to implement the first transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry point for potential volunteers of large-scale ...

    • Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP 

      Pedersen, Gabriel Kristian; Ebensen, Thomas; Gjeraker, Ingrid Hjetland; Svindland, Signe; Bredholt, Geir; Guzmán, Carlos Alberto; Cox, Rebecca Jane (Peer reviewed; Journal article, 2011-11-01)
      Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The ...

    • The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority 

      Sicca, Federica; Sakorafa, Eleni; de Jonge, Anouk; de Vries-Idema, Jacqueline; Zhou, Fan; Cox, Rebecca Jane; Huckriede, Anke (Journal article; Peer reviewed, 2022)
      The high genetic and antigenic variability of influenza virus and the repeated exposures of individuals to the virus over time account for the human immune responses toward this pathogen to continuously evolve during the ...

    • Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward 

      Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)
      Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ...

    • The expression of B & T cell activation markers in children’s tonsils following live attenuated influenza vaccine 

      Panapasa, Jack A.; Cox, Rebecca Jane; Mohn, Kristin Greve-Isdahl; Aqrawi, Lara Adnan; Brokstad, Karl Albert (Peer reviewed; Journal article, 2015-07-06)
      Live attenuated influenza vaccines (LAIV) can prevent influenza illness and death in children. The absence of known correlates of protection induced by LAIV requires human studies of underlying mechanisms of vaccine-induced ...

    • An external quality assessment feasibility study; cross laboratory comparison of haemagglutination inhibition assay and microneutralization assay performance for seasonal influenza serology testing: A FLUCOP study 

      Waldock, Joanna; Weiss, Carol D.; Wang, Wei; Levine, Min Z.; Jefferson, Stacie N.; Ho, Sammy; Hoschler, Katja; Londt, Brandon Z.; Masat, Elisa; Carolan, Louise; Sánchez-Ovando, Stephany; Fox, Annette; Watanabe, Shinji; Akimoto, Miki; Sato, Aya; Kishida, Noriko; Buys, Amelia; Maake, Lorens; Fourie, Cardia; Caillet, Catherine; Raynaud, Sandrine; Webby, Richard J.; DeBeauchamp, Jennifer; Cox, Rebecca Jane; Jalloh, Sarah Larteley Lartey; Trombetta, Claudia M.; Marchi, Serena; Montomoli, Emanuele; Sanz-Muñoz, Iván; Eiros, José María; Sánchez-Martínez, Javier; Duijsings, Danny; Engelhardt, Othmar G. (Journal article; Peer reviewed, 2023)
      Introduction: External Quality Assessment (EQA) schemes are designed to provide a snapshot of laboratory proficiency, identifying issues and providing feedback to improve laboratory performance and inter-laboratory agreement ...

    • Factors that impact on recruitment to vaccine trials during a pandemic or epidemic: a qualitative evidence synthesis 

      Meskell, Pauline; Biesty, Linda M; Dowling, Maura; Meehan, Elaine; Glenton, Claire; Devane, Declan; Shepperd, Sasha; Booth, Andrew; Cox, Rebecca Jane; Chan, Xin Hui S; Houghton, Catherine (Journal article; Peer reviewed, 2022)
      This is a protocol for a Cochrane Review (qualitative). The review aims to explore the factors associated with a person’s decision to take part in a pandemic or epidemic vaccine trial.

    • Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014) 

      Amdam, Håkon; Madsen, Anders; Zhou, Fan; Bansal, Amit; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ...