Blar i Bergen Open Research Archive på forfatter "Crapo, James D."

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    • DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease 

      Lee, Jin H.; McDonald, Merry-Lynn N.; Cho, Michael H.; Wan, Emily S.; Castaldi, Peter J.; Hunninghake, Gary M.; Marchetti, Nathaniel; Lynch, David A.; Crapo, James D.; Lomas, David A.; Coxson, Harvey O.; Bakke, Per; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2014-08-20)
      Background: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of ...

    • Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease 

      Lee, Jin H.; Cho, Michael H.; Hersh, Craig P.; McDonald, Merry-Lynn N.; Crapo, James D.; Bakke, Per; Gulsvik, Amund; Comellas, Alejandro P.; Wendt, Christine H.; Lomas, David A.; Kim, Victor; Silverman, Edwin K.; on behalf of the COPDGene and ECLIPSE Investigators (Peer reviewed; Journal article, 2014-09-21)
      Background: Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and ...

    • Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease 

      Qiu, Weiliang; Cho, Michael H.; Riley, John H.; Anderson, Wayne H.; Singh, Dave; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A.; Lomas, David A.; Crapo, James D.; Beaty, Terri H.; Celli, Bartolome R.; Rennard, Stephen I.; Tal-Singer, Ruth; Fox, Steven M.; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2011-09-16)
      Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We ...

    • X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study 

      Hayden, Lystra P.; Hobbs, Brian D.; Busch, Robert; Cho, Michael H.; Liu, Ming; Lopes-Ramos, Camila M.; Lomas, David A.; Bakke, Per S.; Gulsvik, Amund; Silverman, Edwin K.; Crapo, James D.; Beaty, Terri H.; Laird, Nan M.; Lange, Christoph; DeMeo, Dawn L. (Journal article; Peer reviewed, 2023)
      Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related ...