• The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths 

      Ousdal, Olga Therese; Milde, Anne Marita; Hafstad, Gertrud Sofie; Hodneland, Erlend; Dyb, Grete; Craven, Alexander R.; Melinder, Annika Maria D; Endestad, Tor; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following ...
    • Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites 

      Mikkelsen, Mark; Rimbault, Daniel L.; Barker, Peter B.; Bhattacharyya, Pallab K.; Brix, Maiken Kirkegaard; Buur, Pieter F.; Cecil, Kim M.; Chan, Kimberly L.; Chen, David Y.-T.; Craven, Alexander R.; Cuypers, Koen; Dacko, Michael; Duncan, Niall W.; Dydak, Ulrike; Edmondson, David A.; Ende, Gabriele; Ersland, Lars; Forbes, Megan A.; Gao, Fei; Greenhouse, Ian; Harris, Ashley D.; He, Naying; Heba, Stefanie; Hoggard, Nigel; Hsu, Tun-Wei; Jansen, Jacobus F.A.; Kangarlu, Alayar; Lange, Thomas; Lebel, R. Marc; Li, Yan; Lin, Chien-Yuan E.; Liou, Jy-Kang; Lirng, Jiing-Feng; Liu, Feng; Long, Joanna R.; Ma, Ruoyun; Maes, Celine; Moreno-Ortega, Marta; Murray, Scott O.; Noah, Sean; Noeske, Ralph; Noseworthy, Michael D.; Oeltzschner, Georg; Porges, Eric C.; Prisciandaro, James J.; Puts, Nicolaas A.J.; Roberts, Timothy P.L.; Sack, Markus; Sailasuta, Napapon; Saleh, Muhammad G.; Schallmo, Michael-Paul; Simard, Nicholas; Stoffers, Diederick; Swinnen, Stephan P.; Tegenthoff, Martin; Truong, Peter; Wang, Guangbin; Wilkinson, Iain D.; Wittsack, Hans-Jörg; Woods, Adam J.; Xu, Hongmin; Yan, Fuhua; Zhang, Chencheng; Zipunnikov, Vadim; Zöllner, Helge J.; Edden, Richard A.E. (Peer reviewed; Journal article, 2019)
      Accurate and reliable quantification of brain metabolites measured in vivo using 1H magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from differences in the basic approach to quantification, ...
    • Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • “Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited” 

      Brix, Maiken Kirkegaard; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate; Posserud, Maj-Britt; Hammar, Åse; Craven, Alexander R.; Noeske, Ralph; Evans, C. John; Walker, Hanne B.; Midtvedt, Tore; Beyer, Mona K. (Peer reviewed; Journal article, 2015-06-22)
      Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) ...
    • Combined fMRI Region- and Network-Analysis Reveal New Insights of Top-Down Modulation of Bottom-Up Processes in Auditory Laterality 

      Kazimierczak, Katarzyna; Craven, Alexander R.; Ersland, Lars; Specht, Karsten; Dumitru, Magda L.; Sandøy, Lydia B.; Hugdahl, Kenneth (Journal article; Peer reviewed, 2022)
      Dichotic listening along with the right-ear advantage (REA) has been a standard method of investigating auditory laterality ever since it was first introduced into neuropsychology in the early 1960s. Beginning in the 1980s, ...
    • Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites 

      Považan, Michal; Mikkelsen, Mark; Berrington, Adam; Bhattacharyya, Pallab K.; Brix, Maiken Kirkegaard; Buur, Pieter F.; Cecil, Kim M.; Chan, Kimberly L.; Chen, David Y.T.; Craven, Alexander R.; Cuypers, Koen; Dacko, Michael; Duncan, Niall W.; Dydak, Ulrike; Edmondson, David A.; Ende, Gabriele; Ersland, Lars; Forbes, Megan A.; Gao, Fei; Ian, Greenhouse; Harris, Ashley D.; He, Naying; Heba, Stefanie; Hoggard, Nigel; Hsu, Tun-Wei; Jansen, Jacobus F. A.; Kangarlu, Alayar; Lange, Thomas; Lebel, R. Marc; Li, Yan; Lin, Chien-Yuan E.; Liou, Jy-Kang; Lirng, Jiing-Feng; Liu, Feng; Long, Joanna R.; Ma, Ruoyun; Maes, Celine; Moreno-Ortega, Marta; Murray, Scott O.; Noah, Sean; Noeske, Ralph; Noseworthy, Michael D.; Oeltzschner, Georg; Porges, Eric C.; Prisciandaro, James J.; Puts, Nicolaas A. J.; Roberts, Timothy P. L.; Sack, Markus; Sailasuta, Napapon; Saleh, Muhammad G.; Schallmo, Michael-Paul; Simard, Nicholas; Stoffers, Diederick; Swinnen, Stephan P.; Tegenthoff, Martin; Truong, Peter; Wang, Guangbin; Wilkinson, Iain D.; Wittsack, Hans-Jörg; Woods, Adam J.; Xu, Hongmin; Yan, Fuhua; Zhang, Chencheng; Zipunnikov, Vadim; Zöllner, Helge J.; Edden, Richard A.E.; Barker, Peter B. (Journal article; Peer reviewed, 2020)
      Background: The hardware and software differences between MR vendors and individual sites influence the quantification of MR spectroscopy data. An analysis of a large data set may help to better understand sources of the ...
    • Comparison of seven modelling algorithms for γ-aminobutyric acid–edited proton magnetic resonance spectroscopy 

      Craven, Alexander R.; Bhattacharyya, Pallab K.; Clarke, William T.; Dydak, Ulrike; Edden, Richard A.E.; Ersland, Lars; Mandal, Pravat K.; Mikkelsen, Mark; Murdoch, James B.; Near, Jamie; Rideaux, Reuben; Shukla, Deepika; Wang, Min; Wilson, Martin; Zöllner, Helge J.; Hugdahl, Kenneth Jan; Oeltzschner, Georg (Journal article; Peer reviewed, 2022)
      Edited MRS sequences are widely used for studying γ-aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting ...
    • Comparison of seven modelling algorithms for γ-aminobutyric acid–edited proton magnetic resonance spectroscopy 

      Craven, Alexander R.; Bhattacharyya, Pallab K.; Clarke, William T.; Dydak, Ulrike; Edden, Richard A.E.; Ersland, Lars; Mandal, Pravat K.; Mikkelsen, Mark; Murdoch, James B.; Near, Jamie; Rideaux, Reuben; Shukla, Deepika; Wang, Min; Wilson, Martin; Zöllner, Helge J.; Hugdahl, Kenneth; Oeltzschner, Georg (Journal article; Peer reviewed, 2022)
      Edited MRS sequences are widely used for studying γ-aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting ...
    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craven, Alexander R.; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...
    • Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study 

      Weber, Sarah; Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2021)
      Background: Auditory verbal hallucinations (AVH) have been linked to aberrant interhemispheric connectivity between the left and the right superior temporal gyrus (STG), labeled the interhemispheric miscommunication theory. ...
    • Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment 

      Kompus, Kristiina; Volehaugen, Vegard; Craven, Alexander R.; Specht, Karsten (Journal article; Peer reviewed, 2020)
      In a stable environment the brain can minimize processing required for sensory input by forming a predictive model of the surrounding world and suppressing neural response to predicted stimuli. Unpredicted stimuli lead to ...
    • Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia 

      Falkenberg, Liv Eggset; Westerhausen, René; Craven, Alexander R.; Kroken, Rune A.; Løberg, Else-Marie; Specht, Karsten; Hugdahl, Kenneth (Peer reviewed; Journal article, 2014-04-02)
      Schizophrenia is characterized by impaired cognitive functioning, and brain regions involved in cognitive control processes show marked glutamatergic abnormalities. However, it is presently unclear whether aberrant neuronal ...
    • Interactive visual exploration of metabolite ratios in MR spectroscopy studies 

      Garrison, Laura; Vašíček, Jakub; Craven, Alexander R.; Grüner, Renate; Smit, Noeska Natasja; Bruckner, Stefan (Journal article; Peer reviewed, 2020)
      Magnetic resonance spectroscopy (MRS) is an advanced biochemical technique used to identify metabolic compounds in living tissue. While its sensitivity and specificity to chemical imbalances render it a valuable tool in ...
    • Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia. 

      Hjelmervik, Helene; Craven, Alexander R.; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)
      Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ...
    • Multi-vendor standardized sequence for edited magnetic resonance spectroscopy 

      Saleh, Muhammad G.; Rimbault, Daniel; Mikkelsen, Mark; Oeltzschner, Georg; Wang, Anna M; Jiang, Dengrong; Alhamud, Ali; Near, Jamie; Schär, Michael; Noeske, Ralph; Murdoch, James B; Ersland, Lars; Craven, Alexander R.; Dwyer, Gerard Eric; Grüner, Renate; Pan, Li; Ahn, Sinyeob; Edden, Richard A.E. (Peer reviewed; Journal article, 2019)
      Spectral editing allows direct measurement of low-concentration metabolites, such as GABA, glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho)physiology. The most widely used spectral editing ...
    • A multimodal study of the effects of tDCS on dorsolateral prefrontal and temporo-parietal areas during dichotic listening 

      Marquardt, Lynn Anne; Kusztrits, Isabella; Craven, Alexander R.; Hugdahl, Kenneth; Specht, Karsten; Hirnstein, Marco (Journal article; Peer reviewed, 2020)
      The underlying neural mechanisms of transcranial direct current stimulation (tDCS), especially beyond the primary motor cortex, remain unclear. Several studies examined tDCS effects on either functional activity, ...
    • The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease 

      Brakedal, Brage; Dölle, Christian; Riemer, Frank; Ma, Yilong; Nido, Gonzalo Sanchez; Skeie, Geir Olve; Craven, Alexander R.; Schwarzlmüller, Thomas; Brekke, Njål; Diab, Joseph; Sverkeli, Lars Jansen; Skjeie, Vivian; Varhaug, Kristin Nielsen; Tysnes, Ole-Bjørn; Peng, Shichun; Haugarvoll, Kristoffer; Ziegler, Mathias; Grüner, Renate; Eidelberg, David; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), is safe, augments cerebral NAD levels, ...
    • Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients 

      Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Sinkeviciute, Igne; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Grüner, Eli Renate; Sommer, Iris E.; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2021)
      Objectives Negative emotional valence of auditory verbal hallucinations (AVHs) in schizophrenia can be a source of distress and is considered a strong predictor of illness severity. Previous studies have found glutamate ...
    • Neural activation in the ventromedial prefrontal cortex precedes conscious experience of being in or out of a transient hallucinatory state 

      Hugdahl, Kenneth; Craven, Alexander R.; Johnsen, Erik; Ersland, Lars; Stoyanov, Drozdstoy; Kandilarova, Sevdalina; Sandøy, Lydia Brunvoll; Kroken, Rune A.; Løberg, Else-Marie; Sommer, Iris E. (Journal article; Peer reviewed, 2022)
      Background and Hypotheses Auditory verbal hallucinations (AVHs) is not only a common symptom in schizophrenia but also observed in individuals in the general population. Despite extensive research, AVHs are poorly understood, ...
    • No Effects of Anodal tDCS on Local GABA and Glx Levels in the Left Posterior Superior Temporal Gyrus 

      Dwyer, Gerard Eric; Craven, Alexander R.; Hirnstein, Marco; Kompus, Kristiina; Assmus, Jörg; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate (Peer reviewed; Journal article, 2019-01-08)
      A number of studies investigating the biological effects of transcranial direct current stimulation (tDCS) using magnetic resonance spectroscopy (MRS) have found that it may affect local levels of γ-aminobutyric acid (GABA), ...