• In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways 

      Daphu, Inderjit Kaur; Horn, Sindre August; Stieber, Daniel; Varughese, Jobin K.; Spriet, Endy; Dale, Hege Avsnes; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Thorsen, Frits Alan (Peer reviewed; Journal article, 2014-05-16)
      Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAFV600E mutation, which activates the mitogen-activated protein kinase ...
    • A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology 

      Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan (Peer reviewed; Journal article, 2015-11-24)
      Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor mitochondrial ...